Sfoglia per Autore
Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin.
2013-01-01 Robertson, Jc; Hurley, Nc; Tortorici, Marcello; Ciossani, Giuseppe; Borrello, Mt; Vellore, Na; Ganesan, A; Mattevi, Andrea; Baron, R.
Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase.
2013-01-01 Tortorici, Marcello; Borrello, Mt; Tardugno, M; Chiarelli, Laurent; Pilotto, Simona; Ciossani, Giuseppe; Vellore, Na; Bailey, Sg; Cowan, J; O'Connell, M; Crabb, Sj; Packham, G; Mai, A; Baron, R; Ganesan, A; Mattevi, Andrea
Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A.
2014-01-01 Vianello, P; Botrugno, Oa; Cappa, A; Ciossani, Giuseppe; Dessanti, P; Mai, A; Mattevi, Andrea; Meroni, G; Minucci, S; Thaler, F; Tortorici, Marcello; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C.
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities.
2014-01-01 Rotili, D; Tomassi, S; Conte, M; Benedetti, R; Tortorici, Marcello; Ciossani, Giuseppe; Valente, S; Marrocco, B; Labella, D; Novellino, E; Mattevi, Andrea; Altucci, L; Tumber, A; Yapp, C; King, On; Hopkinson, Rj; Kawamura, A; Schofield, Cj; Mai, A.
Differential properties of transcriptional complexes formed by the CoREST family.
2014-01-01 Barrios, Ap; Gómez, Av; Sáez, Je; Ciossani, Giuseppe; Toffolo, E; Battaglioli, E; Mattevi, Andrea; Andrés, Me
Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells
2015-01-01 Veronica, Rodriguez; Sergio, Valente; Rovida, Stefano; Dante, Rotili; Giulia, Stazi; Alessia, Lucidi; Ciossani, Giuseppe; Mattevi, Andrea; Oronza A., Botrugno; Paola, Dessanti; Ciro, Mercurio; Paola, Vianello; Saverio, Minucci; Mario, Varasi; Antonello, Mai
Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies
2015-01-01 Valente, S; Rodriguez, V; Mercurio, C; Vianello, P; Saponara, B; Cirilli, R; Ciossani, Giuseppe; Labella, D; Marrocco, B; Ruoppolo, G; Botrugno, Oa; Dessanti, P; Minucci, S; Mattevi, Andrea; Varasi, M; Mai, A.
Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features
2016-01-01 Speranzini, Valentina; Rotili, Dante; Ciossani, Giuseppe; Pilotto, Simona; Marrocco, Biagina; Forgione, Mariantonietta; Lucidi, Alessia; Forneris, Federico; Mehdipour, Parinaz; Velankar, Sameer; Mai, Antonello; Mattevi, Andrea
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship
2017-01-01 Vianello, Paola; Sartori, Luca; Amigoni, Federica; Cappa, Anna; Fagá, Giovanni; Fattori, Raimondo; Legnaghi, Elena; Ciossani, Giuseppe; Mattevi, Andrea; Meroni, Giuseppe; Moretti, Loris; Cecatiello, Valentina; Pasqualato, Sebastiano; Romussi, Alessia; Thaler, Florian; Trifiró, Paolo; Villa, Manuela; Botrugno, Oronza A.; Dessanti, Paola; Minucci, Saverio; Vultaggio, Stefania; Zagarrí, Elisa; Varasi, Mario; Mercurio, Ciro
Versatile medium-throughput strategies for recombinant expression screening in structural biology
2017-01-01 Forneris, Federico; Canciani, Anselmo; Ciossani, Giuseppe; Palamini, Martina; Chiapparino, Antonella; Gabrieli, Paolo; Guarino, SALVATORE ROCCO; Campioni, Matteo; Nenci, Simone; Magnani, Francesca
Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1
2017-01-01 Speranzini, Valentina; Ciossani, Giuseppe; Marabelli, Chiara; Mattevi, Andrea
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration
2017-01-01 Sartori, Luca; Mercurio, Ciro; Amigoni, Federica; Cappa, Anna; Fagá, Giovanni; Fattori, Raimondo; Legnaghi, Elena; Ciossani, Giuseppe; Mattevi, Andrea; Meroni, Giuseppe; Moretti, Loris; Cecatiello, Valentina; Pasqualato, Sebastiano; Romussi, Alessia; Thaler, Florian; Trifiró, Paolo; Villa, Manuela; Vultaggio, Stefania; Botrugno, Oronza A.; Dessanti, Paola; Minucci, Saverio; Zagarrí, Elisa; Carettoni, Daniele; Iuzzolino, Lucia; Varasi, Mario; Vianello, Paola
Structural and biochemical evaluation of Ceratitis capitata OBP22 affinity for odorants involved in inter-sex communication
2018-01-01 Falchetto, M.; Ciossani, G.; Scolari, F.; DI COSIMO, Alessandro; Nenci, S.; Field, L. M.; Mattevi, A.; Zhou, J. -J.; Gasperi, G.; Forneris, F.
A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex
2019-01-01 Marabelli, Chiara; Marrocco, Biagina; Pilotto, Simona; Chittori, Sagar; Picaud, Sarah; Marchese, Sara; Ciossani, Giuseppe; Forneris, Federico; Filippakopoulos, Panagis; Schoehn, Guy; Rhodes, Daniela; Subramaniam, Sriram; Mattevi, Andrea
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin. | 1-gen-2013 | Robertson, Jc; Hurley, Nc; Tortorici, Marcello; Ciossani, Giuseppe; Borrello, Mt; Vellore, Na; Ganesan, A; Mattevi, Andrea; Baron, R. | |
| Protein Recognition by Short Peptide Reversible Inhibitors of the Chromatin-Modifying LSD1/CoREST Lysine Demethylase. | 1-gen-2013 | Tortorici, Marcello; Borrello, Mt; Tardugno, M; Chiarelli, Laurent; Pilotto, Simona; Ciossani, Giuseppe; Vellore, Na; Bailey, Sg; Cowan, J; O'Connell, M; Crabb, Sj; Packham, G; Mai, A; Baron, R; Ganesan, A; Mattevi, Andrea | |
| Synthesis, biological activity and mechanistic insights of 1-substituted cyclopropylamine derivatives: a novel class of irreversible inhibitors of histone demethylase KDM1A. | 1-gen-2014 | Vianello, P; Botrugno, Oa; Cappa, A; Ciossani, Giuseppe; Dessanti, P; Mai, A; Mattevi, Andrea; Meroni, G; Minucci, S; Thaler, F; Tortorici, Marcello; Trifiró, P; Valente, S; Villa, M; Varasi, M; Mercurio, C. | |
| Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. | 1-gen-2014 | Rotili, D; Tomassi, S; Conte, M; Benedetti, R; Tortorici, Marcello; Ciossani, Giuseppe; Valente, S; Marrocco, B; Labella, D; Novellino, E; Mattevi, Andrea; Altucci, L; Tumber, A; Yapp, C; King, On; Hopkinson, Rj; Kawamura, A; Schofield, Cj; Mai, A. | |
| Differential properties of transcriptional complexes formed by the CoREST family. | 1-gen-2014 | Barrios, Ap; Gómez, Av; Sáez, Je; Ciossani, Giuseppe; Toffolo, E; Battaglioli, E; Mattevi, Andrea; Andrés, Me | |
| Pyrrole- and indole-containing tranylcypromine derivatives as novel lysine-specific demethylase 1 inhibitors active on cancer cells | 1-gen-2015 | Veronica, Rodriguez; Sergio, Valente; Rovida, Stefano; Dante, Rotili; Giulia, Stazi; Alessia, Lucidi; Ciossani, Giuseppe; Mattevi, Andrea; Oronza A., Botrugno; Paola, Dessanti; Ciro, Mercurio; Paola, Vianello; Saverio, Minucci; Mario, Varasi; Antonello, Mai | |
| Pure Diastereomers of a Tranylcypromine-Based LSD1 Inhibitor: Enzyme Selectivity and In-Cell Studies | 1-gen-2015 | Valente, S; Rodriguez, V; Mercurio, C; Vianello, P; Saponara, B; Cirilli, R; Ciossani, Giuseppe; Labella, D; Marrocco, B; Ruoppolo, G; Botrugno, Oa; Dessanti, P; Minucci, S; Mattevi, Andrea; Varasi, M; Mai, A. | |
| Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features | 1-gen-2016 | Speranzini, Valentina; Rotili, Dante; Ciossani, Giuseppe; Pilotto, Simona; Marrocco, Biagina; Forgione, Mariantonietta; Lucidi, Alessia; Forneris, Federico; Mehdipour, Parinaz; Velankar, Sameer; Mai, Antonello; Mattevi, Andrea | |
| Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship | 1-gen-2017 | Vianello, Paola; Sartori, Luca; Amigoni, Federica; Cappa, Anna; Fagá, Giovanni; Fattori, Raimondo; Legnaghi, Elena; Ciossani, Giuseppe; Mattevi, Andrea; Meroni, Giuseppe; Moretti, Loris; Cecatiello, Valentina; Pasqualato, Sebastiano; Romussi, Alessia; Thaler, Florian; Trifiró, Paolo; Villa, Manuela; Botrugno, Oronza A.; Dessanti, Paola; Minucci, Saverio; Vultaggio, Stefania; Zagarrí, Elisa; Varasi, Mario; Mercurio, Ciro | |
| Versatile medium-throughput strategies for recombinant expression screening in structural biology | 1-gen-2017 | Forneris, Federico; Canciani, Anselmo; Ciossani, Giuseppe; Palamini, Martina; Chiapparino, Antonella; Gabrieli, Paolo; Guarino, SALVATORE ROCCO; Campioni, Matteo; Nenci, Simone; Magnani, Francesca | |
| Probing the interaction of the p53 C-terminal domain to the histone demethylase LSD1 | 1-gen-2017 | Speranzini, Valentina; Ciossani, Giuseppe; Marabelli, Chiara; Mattevi, Andrea | |
| Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 1: High-Throughput Screening and Preliminary Exploration | 1-gen-2017 | Sartori, Luca; Mercurio, Ciro; Amigoni, Federica; Cappa, Anna; Fagá, Giovanni; Fattori, Raimondo; Legnaghi, Elena; Ciossani, Giuseppe; Mattevi, Andrea; Meroni, Giuseppe; Moretti, Loris; Cecatiello, Valentina; Pasqualato, Sebastiano; Romussi, Alessia; Thaler, Florian; Trifiró, Paolo; Villa, Manuela; Vultaggio, Stefania; Botrugno, Oronza A.; Dessanti, Paola; Minucci, Saverio; Zagarrí, Elisa; Carettoni, Daniele; Iuzzolino, Lucia; Varasi, Mario; Vianello, Paola | |
| Structural and biochemical evaluation of Ceratitis capitata OBP22 affinity for odorants involved in inter-sex communication | 1-gen-2018 | Falchetto, M.; Ciossani, G.; Scolari, F.; DI COSIMO, Alessandro; Nenci, S.; Field, L. M.; Mattevi, A.; Zhou, J. -J.; Gasperi, G.; Forneris, F. | |
| A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex | 1-gen-2019 | Marabelli, Chiara; Marrocco, Biagina; Pilotto, Simona; Chittori, Sagar; Picaud, Sarah; Marchese, Sara; Ciossani, Giuseppe; Forneris, Federico; Filippakopoulos, Panagis; Schoehn, Guy; Rhodes, Daniela; Subramaniam, Sriram; Mattevi, Andrea |
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