We have developed a fluorescence-based fiber optic biosensor for detection of general anesthetics. It monitors anesthetic-induced changes in fluorescence emission by labeled liposomes entrapped in a hydrogel at the end of two optical fibers. We have demonstrated that this sensor is sensitive to clinically relevant concentrations of commonly used general anesthetics. The sensor may be used for remote measurements of various lipid-soluble chemicals in gas, liquid or solid phases (e.g., blood and tissue).

An optical method for detecting anesthetics and other lipid-soluble compounds

MERLO, SABINA GIOVANNA;
1990-01-01

Abstract

We have developed a fluorescence-based fiber optic biosensor for detection of general anesthetics. It monitors anesthetic-induced changes in fluorescence emission by labeled liposomes entrapped in a hydrogel at the end of two optical fibers. We have demonstrated that this sensor is sensitive to clinically relevant concentrations of commonly used general anesthetics. The sensor may be used for remote measurements of various lipid-soluble chemicals in gas, liquid or solid phases (e.g., blood and tissue).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/111081
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