Abstract: The development of molecular techniques has added a significant new dimension to the study of experimental pathology and of cellular biology of the kidney. Since the field is relatively new and many methods lack the sensitivity required for small fragments of tissue, there is very little data on renal biopsies [1]. In addition, ethical considerations have limited the amount of tissue that can be devoted to experimental techniques. These have combined to slow progress in understanding the molecular events underlying human renal diseases, but there has been recent clarification by a consensus conference [2]. This review will be restricted to DNA and mRNA detection in renal tissue. We will not consider genetic mutations, such as those present in Alport's disease, since the gene defect is present in all somatic cells and analysis can be performed with circulating cells.

Molecular analysis of human glomerular disease.

ESPOSITO, CIRO;
1996-01-01

Abstract

Abstract: The development of molecular techniques has added a significant new dimension to the study of experimental pathology and of cellular biology of the kidney. Since the field is relatively new and many methods lack the sensitivity required for small fragments of tissue, there is very little data on renal biopsies [1]. In addition, ethical considerations have limited the amount of tissue that can be devoted to experimental techniques. These have combined to slow progress in understanding the molecular events underlying human renal diseases, but there has been recent clarification by a consensus conference [2]. This review will be restricted to DNA and mRNA detection in renal tissue. We will not consider genetic mutations, such as those present in Alport's disease, since the gene defect is present in all somatic cells and analysis can be performed with circulating cells.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/116889
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