Which is the molecular identity of the developmentally competent mouse oocyte? Using a model study in which MII oocytes arrest development at the 2-cell stage, we have brought up an OCT4 transcriptional network (OCT4-TN) that is present in MII oocytes and is maintained in 2-cell embryos and in embryonic stem cells (ESCs). The OCT4-TN provides a developmental link between eggs, early preimplantation embryos and ESCs, indicating that the molecular signature that characterises the ESCs identity may be rooted in oogenesis.

Acquisition of the oocyte developmental competence

ZUCCOTTI, MAURIZIO
;
Valeria Merico;Carlo Alberto Redi;
2013-01-01

Abstract

Which is the molecular identity of the developmentally competent mouse oocyte? Using a model study in which MII oocytes arrest development at the 2-cell stage, we have brought up an OCT4 transcriptional network (OCT4-TN) that is present in MII oocytes and is maintained in 2-cell embryos and in embryonic stem cells (ESCs). The OCT4-TN provides a developmental link between eggs, early preimplantation embryos and ESCs, indicating that the molecular signature that characterises the ESCs identity may be rooted in oogenesis.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1195460
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