Spironolactone is a steroidal diuretic showing incomplete oral behaviour because of its low solubility and slow dissolution rate. Four solid forms were obtained by recrystallisation of a commercial sample from different solvents (acetone, methanol, ethyl acetate). These samples have been characterised by Fourier transform infrared (FT-IR) Spectroscopy, X-ray powder diffraction, thermogravimetric analysis coupled with FT-IR spectroscopy (TG/FT-IR) and differential scanning calorimetry (DSC). The aim of the work is establish evidence for differences, if any, between the forms and, possibly, to understand their nature. A careful analysis of the collected data makes it possible to rule out the presence of any solvate and to distinguish three different polymorphs.

Physico-chemical characterisation of different solid forms of spironolactone

BERBENNI, VITTORIO;MARINI, AMEDEO;BRUNI, GIOVANNA;RICCARDI, RICCARDO;
1999-01-01

Abstract

Spironolactone is a steroidal diuretic showing incomplete oral behaviour because of its low solubility and slow dissolution rate. Four solid forms were obtained by recrystallisation of a commercial sample from different solvents (acetone, methanol, ethyl acetate). These samples have been characterised by Fourier transform infrared (FT-IR) Spectroscopy, X-ray powder diffraction, thermogravimetric analysis coupled with FT-IR spectroscopy (TG/FT-IR) and differential scanning calorimetry (DSC). The aim of the work is establish evidence for differences, if any, between the forms and, possibly, to understand their nature. A careful analysis of the collected data makes it possible to rule out the presence of any solvate and to distinguish three different polymorphs.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/132297
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact