A PILOT STUDY TO EVALUATE THE EFFECTIVENESS OF A MULTIDISCIPLINARY METHOD FOR WEIGHT LOSS WITH KETOGENIC DIET ON CHRONIC INFLAMMATION MARKERS IN OBESE SUBJECTS

Aim of the study: to evaluate the effectiveness of a multidisciplinary method for weight loss ketogenic diet (VLCKD) based on the intake of specific products with high content of protein and omega 3 on markers of chronic inflammation in obese patients. This standardized method combining diet physical activity and psychological support, controlled by a doctor and with dietary-nutritional follow-up. Materials and methods: This is a pilot clinical study, uncontrolled, monocentric, with nutritional guidelines and medical devices. Observation period was 6 months. A total of 12 subjects (3 men and 9 women) generally healthy individuals were participated in the study. Average age was of 50,15 ± 12,16 years and of BMI was of 33,46 ± 1,63 kg/m2. Results: The weight has decreased significantly (p<0,0001) after 2 months (T4); the decrease was of 11,2% (-10,8 kg, whose fat mass -9,1 kg; p<0,0001 and fat free mass -1,6 kg; p<0.001) and maintained at the final visit (T8) with 10,5 % (-10,1 kg whose fat mass -8,5 kg) while a significant increase (p<0,05) of fat free mass 1,6 kg. The waist circumference has decreased significantly (p<0,0001) of 8,6% (-9,4 cm) at T4 and continued to decline at T8 with a decrease (p<0,001) of 11,6% (-12,6). The other important value for the subject's health status is the VAT which in this study has decreased significantly (p<0,001) at T4 and (p<0,01) at T8. Moreover, the study demonstrated an improvement of glycemic control during VLCKD a reduction of insulin level (p<0,001), HbA1c (p<0,0001) and HOMA index (p<0,001). From an inflammatory point of view, there has been a statistically significant reduction in PCR (p<0,01). Conclusions: The method was effective in quality of weight loss. 84% of the lost weight was the fat mass, with the preservation of the fat free mass. An improvement in glycemic metabolic control and a decrease in the inflammatory state of patients in the period with VLCKD (lipo-inflammation resolution) was observed.