We discuss the temperature dependence of the 1 H and 13 C nuclear spin-lattice relaxation rate 1/T 1 and dynamic nuclear polarization (DNP) performance in β-cyclodextrins with deuterated methyl groups. It is shown that 13 C DNP-enhanced polarization is raised up to 10%. The temperature dependence of the buildup rate for nuclear spin polarization and of 1/T 1 , below 4.2 K, is analyzed in the framework of the thermal mixing regime and the origin of the deviations from the theoretical behavior discussed. 13 C 1/T 1 is determined at low temperature by the glassy dynamics and at high temperature by the rotational molecular motions of the deuterated methyl groups. Thanks to deuteration, relaxation times approaching 30 s are achieved at room temperature, making this material interesting for molecular imaging applications. The effect of molecular dynamics on the line width of the NMR spectra is also discussed.

Molecular Dynamics and Hyperpolarization Performance of Deuterated β-Cyclodextrins

Caracciolo F.;Charlaftis E.;Carretta P.
2019-01-01

Abstract

We discuss the temperature dependence of the 1 H and 13 C nuclear spin-lattice relaxation rate 1/T 1 and dynamic nuclear polarization (DNP) performance in β-cyclodextrins with deuterated methyl groups. It is shown that 13 C DNP-enhanced polarization is raised up to 10%. The temperature dependence of the buildup rate for nuclear spin polarization and of 1/T 1 , below 4.2 K, is analyzed in the framework of the thermal mixing regime and the origin of the deviations from the theoretical behavior discussed. 13 C 1/T 1 is determined at low temperature by the glassy dynamics and at high temperature by the rotational molecular motions of the deuterated methyl groups. Thanks to deuteration, relaxation times approaching 30 s are achieved at room temperature, making this material interesting for molecular imaging applications. The effect of molecular dynamics on the line width of the NMR spectra is also discussed.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1333026
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