The berberine bridge enzyme catalyses the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism which couples two distinct chemical steps – oxidation and proton abstraction - affecting two separate groups of the substrate.

Cyclization in concert.

MATTEVI, ANDREA
2008-01-01

Abstract

The berberine bridge enzyme catalyses the crucial step in the biosynthesis of an important class of alkaloids through a reaction that cannot be carried out using conventional organic chemistry tools. Characterization of the enzyme demonstrates a concerted mechanism which couples two distinct chemical steps – oxidation and proton abstraction - affecting two separate groups of the substrate.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/134544
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 4
social impact