In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc2155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn2+ ions.

Rv2358-FurB: two transcriptional regulators from Mycobacterium tuberculosis which respond to zinc

CANNEVA, FABIO;BRANZONI, MANUELA;RICCARDI, GIOVANNA;MILANO, ANNA
2005-01-01

Abstract

In a previous work, we demonstrated that the Mycobacterium tuberculosis Rv2358-furB operon is induced by zinc. In this study, the orthologous genes from Mycobacterium smegmatis mc2155 were inactivated and mutants analyzed. Rv2358 protein was purified and found to bind upstream of the Rv2358 gene. Binding was inhibited by Zn2+ ions.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/134655
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