Advanced multiscale models in computational electrocardiology offer a detailed representation of the heart bioelectrical activity, ranging from the microscopic description of ion channels of the cellular membrane to the macroscopic properties of anisotropic front propagation in the whole heart. Our model consists of a Monodomain or Bidomain tissue representation that includes orthotropic anisotropy, transmural fiber rotation and homogeneous or heterogeneous intrinsic membrane properties, described by Luo-Rudy type models. We consider membrane heterogeneities due either to the presence of midwall cells (M-cells) with different action potential durations (APDs) or to the presence of subendocardial ischemic regions. We present the results of large-scale simulations of an entire heartbeat with epicardial or endocardial pacing of three-dimensional ventricular blocks. We will also discuss some numerical features of our simulations, including parallel scalability, multilevel preconditioning and space-time adaptivity.

Modeling ventricular repolarization: effects of transmural and apex-to-base heterogeneities in action potential durations

COLLI FRANZONE, PIERO;PAVARINO, LUCA FRANCO;
2008-01-01

Abstract

Advanced multiscale models in computational electrocardiology offer a detailed representation of the heart bioelectrical activity, ranging from the microscopic description of ion channels of the cellular membrane to the macroscopic properties of anisotropic front propagation in the whole heart. Our model consists of a Monodomain or Bidomain tissue representation that includes orthotropic anisotropy, transmural fiber rotation and homogeneous or heterogeneous intrinsic membrane properties, described by Luo-Rudy type models. We consider membrane heterogeneities due either to the presence of midwall cells (M-cells) with different action potential durations (APDs) or to the presence of subendocardial ischemic regions. We present the results of large-scale simulations of an entire heartbeat with epicardial or endocardial pacing of three-dimensional ventricular blocks. We will also discuss some numerical features of our simulations, including parallel scalability, multilevel preconditioning and space-time adaptivity.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/139072
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