Pentosan polysulphate sodium (PPS) is the only oral medicine (Elmiron®) FDA approved for treating interstitial cystitis (IC), a rare disease results in recurring discomfort, pressure, tenderness, or intense pain in the bladder and pelvic area. The aim of this work was to develop a new therapeutic system, able to deliver PPS directly to vaginal area, by ionotropic gelation between the polyanionic PPS and polycationic chitosan.
A preliminary study of chitosan-pentosan polysulfate sodium complex as vaginal sustained drug delivery system in a rare disease treatment
PERUGINI, PAOLA;PAVANETTO, FRANCA
2010-01-01
Abstract
Pentosan polysulphate sodium (PPS) is the only oral medicine (Elmiron®) FDA approved for treating interstitial cystitis (IC), a rare disease results in recurring discomfort, pressure, tenderness, or intense pain in the bladder and pelvic area. The aim of this work was to develop a new therapeutic system, able to deliver PPS directly to vaginal area, by ionotropic gelation between the polyanionic PPS and polycationic chitosan.File in questo prodotto:
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