Three series of mononcyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C-4 to C-10 were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA). This study indicates that it is more the length of the acyl chain that is important for the activity, six carbon atoms resulting in maximum effect, rather than the position of the eater function and the nature of the sugar (galactose or glucose). (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

Inhibitory effects of monoacylated 2-O-beta-galactosylglycerols on Epstein-Barr virus activation: the significant role of the hexanoyl chain

TOMA, LUCIO;
1999-01-01

Abstract

Three series of mononcyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C-4 to C-10 were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol- 13-acetate (TPA). This study indicates that it is more the length of the acyl chain that is important for the activity, six carbon atoms resulting in maximum effect, rather than the position of the eater function and the nature of the sugar (galactose or glucose). (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/455841
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