The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide (3) have been observed and rationalized. Expedients have been devised to improve the shelf-life of crystalline 1 up to acceptable levels.

Solid state photoreactivity of a dioxolenone methyl ester

ALBINI, ANGELO;FASANI, ELISA;
1995-01-01

Abstract

The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) was found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxide (3) have been observed and rationalized. Expedients have been devised to improve the shelf-life of crystalline 1 up to acceptable levels.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/460506
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