Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines.

Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane

DORIA, FILIPPO;GERMANI, LUCA;MELLA, MARIELLA;FRECCERO, MAURO;
2013-01-01

Abstract

Naphthalene diimides conjugated to a quinone methide and an oxirane have been synthesized and investigated as selective DNA G-quadruplex alkylating agents. The oxirane derivative generates a stable adduct with a G-quadruplex and shows selective alkylation of the loop adenines.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/602613
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