In order to verify the effect of different processes on the starting polymers INVITE, their thermal properties have been deeply investigated. In particular, micelles from INVITE polymers, at different degrees of substitution in VITE, have been prepared by the dialysis method so obtaining three different micelle systems. The same systems have been further loaded with the hydrophobic drug curcumin with the aim to evaluate the influence of a hydrophobic drug in the micelles core. These studies are aimed to verify whether the tested systems could result stable at physiological temperatures and how the different parameters tested such as lyophilization, micelle formation or drug loading might influence the overall thermal behaviors of the systems for an optimized preparation of the subsequent formulation.
Effect of micelles formation and drug loading on thermal properties of Inulin-graft- Vitamin E (INVITE) polymers
TRIPODO, GIUSEPPE;CATENACCI, LAURA;SORRENTI, MILENA LILLINA
2013-01-01
Abstract
In order to verify the effect of different processes on the starting polymers INVITE, their thermal properties have been deeply investigated. In particular, micelles from INVITE polymers, at different degrees of substitution in VITE, have been prepared by the dialysis method so obtaining three different micelle systems. The same systems have been further loaded with the hydrophobic drug curcumin with the aim to evaluate the influence of a hydrophobic drug in the micelles core. These studies are aimed to verify whether the tested systems could result stable at physiological temperatures and how the different parameters tested such as lyophilization, micelle formation or drug loading might influence the overall thermal behaviors of the systems for an optimized preparation of the subsequent formulation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
