The incidence of genetic instability affecting a set of STRs commonly used in forensic DNA analyses was assessed by performing a comparative study on 24 lung carcinomas with paired normal tissue samples. Out of 24 samples, 20 (83%) showed allele drop-out (ADO) in at least one STR locus. Allelic imbalance was detected at all the STR loci analysed. A small-cell carcinoma sample showed loss of heterozygosity (LOH), with complete deletion of one allele, at the D5S818 and D13S317 loci.

Forensic evaluation of tetranucleotide STR instability in lung cancer

PELOSO, GABRIELLA;GRIGNANI, PIERANGELA;ROSSO, RENATO;PREVIDERE', CARLO
2003-01-01

Abstract

The incidence of genetic instability affecting a set of STRs commonly used in forensic DNA analyses was assessed by performing a comparative study on 24 lung carcinomas with paired normal tissue samples. Out of 24 samples, 20 (83%) showed allele drop-out (ADO) in at least one STR locus. Allelic imbalance was detected at all the STR loci analysed. A small-cell carcinoma sample showed loss of heterozygosity (LOH), with complete deletion of one allele, at the D5S818 and D13S317 loci.
2003
9780444507174
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/9297
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