Epidemiology of sudden cardiac death in Cameroon: rationale and design of the Douala-SUD survey

BACKGROUND: The burden of sudden unexplained death in sub-Saharan Africa is unknown. AIM: The aim of this study is to establish the epidemiology of sudden cardiac death in Cameroon. METHODS: The Douala sudden unexplained death (Douala-SUD) study is a prospective, multiple-source, community-based surveillance of all cases of unexpected death (< 24 hours from onset of symptoms) occurring in victims aged>15 years. After approval from institutional boards, all deaths occurring in residents of four areas of Douala city will be checked for circumstances of death and past medical history. Subjects who die naturally will be further investigated. Unexpected death victims will be checked for detailed demographic, clinical, electrocardiographic, echocardiographic and biological records. Autopsy background and genetic analysis (postmortem or in first relatives if the young victim is aged<40 years) will be performed as far as possible. Finally, the use of cardiopulmonary resuscitation efforts during the timeframe of sudden cardiac arrest will also be evaluated. CONCLUSION: The Douala-SUD study will provide comprehensive, contemporary data on the epidemiology of sudden unexplained and cardiac death in sub-Saharan Africa and will help in the development of strategies to prevent and manage cardiac arrest in Cameroon as well as in other sub-Saharan countries. Copyright © 2014 Elsevier Masson SAS. All rights reserved. KEYWORDS: Afrique subsaharienne; Arrêt cardiaque; Arythmies ventriculaires; Cardiac arrest; Cardiopathie ischémique; Coronary artery disease; Mort subite inexpliquée; Sub-Saharan Africa; Sudden unexplained death; Ventricular arrhythmias