Electrochemical techniques have been successfully employed for the determination of two atypical antipsychotics, aripiprazole and octoclothepin, in pharmaceutical formulations and in biological fluids, with the aim to propose a method alternative to chromatography. We explored as well their electrochemical behavior and the use of DFT (Density Functional Theory) calculations substantially contributed to the rationalization of their electrochemistry. Thus, the mentioned compounds were analyzed in pharmaceutical forms by Linear Scan Voltammetry (LSV). A stripping voltammetric method (AdSV) was optimized for their determination in the lg L1 range, concentration expected in biological samples such as urine.

Electrochemistry and analytical determination of aripiprazole and octoclothepin at glassy carbon electrode

MERLI, DANIELE;DONDI, DANIELE;RAVELLI, DAVIDE;PROFUMO, ANTONELLA
2013-01-01

Abstract

Electrochemical techniques have been successfully employed for the determination of two atypical antipsychotics, aripiprazole and octoclothepin, in pharmaceutical formulations and in biological fluids, with the aim to propose a method alternative to chromatography. We explored as well their electrochemical behavior and the use of DFT (Density Functional Theory) calculations substantially contributed to the rationalization of their electrochemistry. Thus, the mentioned compounds were analyzed in pharmaceutical forms by Linear Scan Voltammetry (LSV). A stripping voltammetric method (AdSV) was optimized for their determination in the lg L1 range, concentration expected in biological samples such as urine.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/983055
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 17
social impact