IRIS

The present invention relates to a modified HGF-1K1 polypeptide (such as that shown in Seq ID No:4), and certain mutations for the disruption of an identified glycosylation site, DNA sequences encoding those proteins (such as those sequences in Seq ID NO: 5 and 6) and various methods for their production. The invention also relates to pharmaceutical compositions containing the modified HGF-1K1 polypeptides and to their use in the treatment of various diseases such as COPD, broncheolitis obliterans, acute lung injury (ALI), idiopathic pulmonary fibrosis (IPF), myocardial infarction, liver fibrosis and kidney fibrosis.

MODIFIED HGF-1K1 POLYPEPTIDE.

GHERARDI, ERMANNO;
2012-01-01

Abstract

The present invention relates to a modified HGF-1K1 polypeptide (such as that shown in Seq ID No:4), and certain mutations for the disruption of an identified glycosylation site, DNA sequences encoding those proteins (such as those sequences in Seq ID NO: 5 and 6) and various methods for their production. The invention also relates to pharmaceutical compositions containing the modified HGF-1K1 polypeptides and to their use in the treatment of various diseases such as COPD, broncheolitis obliterans, acute lung injury (ALI), idiopathic pulmonary fibrosis (IPF), myocardial infarction, liver fibrosis and kidney fibrosis.
2012
Biochemistry & Biophysics focuses on the structure and chemistry of biomolecules and covers all aspects of basic biochemistry/biophysics, including molecular structure, enzyme kinetics and protein-protein interaction; this category also contains cross-disciplinary resources focused on a specific class of biological molecules, e.g., nucleic acids, steroids, magnesium, growth factors, free radicals, bio-membranes, and peptides. Excluded are resources dealing with the application of biochemical techniques to specific topics listed elsewhere in CC/LS. Resources with a strong emphasis on the integration of biochemical pathways (such as signal transduction or molecular motors) at the cellular level are placed in the Cell & Developmental Biology category.
WO/2013/037521
UK MEDICAL RESEARCH COUNCIL
ELETTRONICO
Inglese
sì
6 Brevetti::6.1 Brevetto
none
Gherardi, Ermanno; Lietha, Daniel
info:eu-repo/semantics/patent
285
2
6.1 Brevetto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1183782
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