IRIS

A method of monitoring the progress of a chem. reaction carried out on a solid support comprises (a) derivatizing a sample of a bound compd. with phenylisocyanate (PIC) as a labeling moiety, (b) cleaving the derivatized compd. from the solid support, and (c) detg. the amt. of derivatized compd. by HPLC with UV detection. The reaction of several arom. aldehydes with resin-​bound β-​alanine to produce a series of imines was monitored by HPLC using the PIC derivatization method to det. the amt. of unreacted β-​alanine present. The superior and consistent results from the PIC method were obtained over a mass spectrometric method.

Derivatization with phenylisocyanate for HPLC monitoring of chemical reactions

Zanoni Giuseppe.
Conceptualization
1999-01-01

Abstract

A method of monitoring the progress of a chem. reaction carried out on a solid support comprises (a) derivatizing a sample of a bound compd. with phenylisocyanate (PIC) as a labeling moiety, (b) cleaving the derivatized compd. from the solid support, and (c) detg. the amt. of derivatized compd. by HPLC with UV detection. The reaction of several arom. aldehydes with resin-​bound β-​alanine to produce a series of imines was monitored by HPLC using the PIC derivatization method to det. the amt. of unreacted β-​alanine present. The superior and consistent results from the PIC method were obtained over a mass spectrometric method.
1999
21-lug-1999
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
WO 2000005578
Smithkline Beecham S.p.A., Italy
STAMPA
Inglese
Internazionale
Solid Supported, derivatisation, HPLC.
no
6 Brevetti::6.1 Brevetto
none
Artico, Marco; Mena, Renzo; Zanoni, Giuseppe.
info:eu-repo/semantics/patent
285
3
6.1 Brevetto
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1213027
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact