Poster N. 21 - In near-physiological conditions (1.3 mM extracellular Ca2+ and body temperature), the Ca2+-dependence of neurotransmitter release in mature mouse VHCs is high-order. This result differs from the linear coupling reported by Dulon et al. (2009), presumably due to the different experimental conditions they employed (5 mM extracellular Ca2+ and room temperature). The supralinear nature of the relationship between Ca2+ influx and exocytosis in VHCs, which resembles the one found in mature apical cochlear IHCs, is presumably apt to process low-frequency vestibular stimuli.
Supra-linear Ca2+ dependence of the neurotransmitter release at mammalian vestibular ribbon synapses
Paolo Spaiardi
;Sergio Masetto;
2018-01-01
Abstract
Poster N. 21 - In near-physiological conditions (1.3 mM extracellular Ca2+ and body temperature), the Ca2+-dependence of neurotransmitter release in mature mouse VHCs is high-order. This result differs from the linear coupling reported by Dulon et al. (2009), presumably due to the different experimental conditions they employed (5 mM extracellular Ca2+ and room temperature). The supralinear nature of the relationship between Ca2+ influx and exocytosis in VHCs, which resembles the one found in mature apical cochlear IHCs, is presumably apt to process low-frequency vestibular stimuli.File in questo prodotto:
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