The present invention is based on the finding that a camelid single domain antibody (sdAb) can be engineered for providing it with asparaginolytic activity; the obtained sdASNase molecule proved to be unexpectedly active and stable and could be targeted onto cancer cells by an antibody.
Targeted single domain antibodies with catalytic activity (T-CAN)
Claudia Scotti
;Maristella Maggi
2018-01-01
Abstract
The present invention is based on the finding that a camelid single domain antibody (sdAb) can be engineered for providing it with asparaginolytic activity; the obtained sdASNase molecule proved to be unexpectedly active and stable and could be targeted onto cancer cells by an antibody.File in questo prodotto:
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