By combining the same active ingredient in a form which is readily soluble in water or aqueous liquids and in a delayed and programmable release form in the same solid pharmaceutical form for oral administration, preferably in the form of a double-layered tablet, high plasma levels are obtained immediately after administration which lead to a consequently rapid therapeutic effect and the maintenance of high plasma levels over a prolonged period after administration. The two forms of active ingredient are accompanied by suitable adjuvants and excipients which are capable of causing the rapid disintegration of the layer containing the active ingredient in a readily soluble form and the delayed release of the active ingredient in the delayed release form.
Solid pharmaceutical form for oral useComprising combined rapid and slow release layers
CONTE, UBALDO;MAGGI, LAURETTA;
1995-01-01
Abstract
By combining the same active ingredient in a form which is readily soluble in water or aqueous liquids and in a delayed and programmable release form in the same solid pharmaceutical form for oral administration, preferably in the form of a double-layered tablet, high plasma levels are obtained immediately after administration which lead to a consequently rapid therapeutic effect and the maintenance of high plasma levels over a prolonged period after administration. The two forms of active ingredient are accompanied by suitable adjuvants and excipients which are capable of causing the rapid disintegration of the layer containing the active ingredient in a readily soluble form and the delayed release of the active ingredient in the delayed release form.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
