A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts.
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Titolo: | A process for the preparation of Tolterodine and intermediates thereof | |
Autori: | ||
Data di pubblicazione: | 2005 | |
Abstract: | A process for the preparation of 6-methyl-4-(R)-phenyl-chroman-2-one and 6-methyl-4-(S)-phenyl-chroman-2-one, intermediates for the synthesis of tolterodine and its (S) enantiomer, by reaction of 6-methyl-coumarin with phenylboronic acids, esters and derivatives thereof, in the presence of chiral catalysts. | |
Handle: | http://hdl.handle.net/11571/21773 | |
Appare nelle tipologie: | 6.1 Brevetto |
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