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EnglishA process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR 1 group, wherein R 1 is C 1 -C 6 alkyl or phenyl optionally substituted by a -O-(CH 2 ) n -phenyl group, wherein n is an integer of 1 to 6; comprising reacting a compound of formula (II) or a salt thereof, both as the individual isomer and as an isomeric mixture, wherein R is as defined above; with a dehydrating agent, if necessary in the presence of an organic solvent, and optionally in the presence of a basic agent; and, if desired, converting a compound of formula (I) to another compound of formula (I) or a salt thereof.
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| Titolo: | A process for the preparation of nitrile compounds used as intermediates in the synthesis of cysteinyl leukotrienes antagonists |
| Autori: | |
| Data di pubblicazione: | 2008 |
| Abstract: | A process for the preparation of a compound of formula (I) or a salt thereof wherein R is an amino, nitro or -NHCOR 1 group, wherein R 1 is C 1 -C 6 alkyl or phenyl optionally substituted by a -O-(CH 2 ) n -phenyl group, wherein n is an integer of 1 to 6; comprising reacting a compound of formula (II) or a salt thereof, both as the individual isomer and as an isomeric mixture, wherein R is as defined above; with a dehydrating agent, if necessary in the presence of an organic solvent, and optionally in the presence of a basic agent; and, if desired, converting a compound of formula (I) to another compound of formula (I) or a salt thereof. |
| Handle: | http://hdl.handle.net/11571/32704 |
| Appare nelle tipologie: | 6.1 Brevetto |
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