PORCARI, RICCARDO
PORCARI, RICCARDO
DIPARTIMENTO DI MEDICINA MOLECOLARE
A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis
2015-01-01 Marcoux, Julien; Mangione, Palma; Porcari, Riccardo; Degiacomi, Matteo T.; Verona, Guglielmo; Taylor, Graham W; Giorgetti, Sofia; Raimondi, Sara; Sanglier Cianférani, Sarah; Benesch, Justin Lp; Cecconi, Ciro; Naqvi, Mohsin M.; Gillmore, Julian D.; Hawkins, Philip N.; Stoppini, Monica; Robinson, Carol V.; Pepys, Mark B.; Bellotti, Vittorio
A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo
2017-01-01 Raimondi, Sara; Porcari, Riccardo; Mangione, Palma; Verona, Guglielmo; Marcoux, Julien; Giorgetti, Sofia; Taylor, Graham W.; Ellmerich, Stephan; Ballico, Maurizio; Zanini, Stefano; Pardon, Els; Al Shawi, Raya; Simons, J. Paul; Corazza, Alessandra; Fogolari, Federico; Leri, Manuela; Stefani, Massimo; Bucciantini, Monica; Gillmore, Julian D.; Hawkins, Philip N.; Valli, Maurizia; Stoppini, Monica; Robinson, Carol V.; Steyaert, Jan; Esposito, Gennaro; Bellotti, Vittorio
Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component
2017-01-01 Ozawa, Daisaku; Nomura, Ryo; Mangione, Palma; Hasegawa, Kazuhiro; Okoshi, Tadakazu; Porcari, Riccardo; Bellotti, Vittorio; Naiki, Hironobu
C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype.
2012-01-01 L., Diomede; Soria, Cristina; M., Romeo; Giorgetti, Sofia; Marchese, Loredana; Mangione, Palma; Porcari, Riccardo; Zorzoli, Irene; M., Salmona; Bellotti, Vittorio; Stoppini, Monica
Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS
2016-01-01 Natalello, Antonino; Mangione, Palma; Giorgetti, Sofia; Porcari, Riccardo; Marchese, Loredana; Zorzoli, Irene; Relini, Annalisa; Ami, Diletta; Faravelli, Giulia; Valli, Maurizia; Stoppini, Monica; Doglia, Silvia M; Bellotti, Vittorio; Raimondi, Sara
Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity
2018-01-01 Le Marchand, Tanguy; De Rosa, Matteo; Salvi, Nicola; Sala, Benedetta Maria; Andreas, Loren B.; Barbet-Massin, Emeline; Sormanni, Pietro; Barbiroli, Alberto; Porcari, Riccardo; Sousa Mota, Cristiano; De Sanctis, Daniele; Bolognesi, Martino; Emsley, Lyndon; Bellotti, Vittorio; Blackledge, Martin; Camilloni, Carlo; Pintacuda, Guido; Ricagno, Stefano
D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile
2016-01-01 Valleix, Sophie; Verona, Guglielmo; Jourde Chiche, Noémie; Nédelec, Brigitte; Mangione, Palma; Bridoux, Frank; Mangé, Alain; Dogan, Ahmet; Goujon, Jean Michel; Lhomme, Marie; Dauteuille, Carolane; Chabert, Michèle; Porcari, Riccardo; Waudby, Christopher A; Relini, Annalisa; Talmud, Philippa J; Kovrov, Oleg; Olivecrona, Gunilla; Stoppini, Monica; Christodoulou, John; Hawkins, Philip N; Grateau, Gilles; Delpech, Marc; Kontush, Anatol; Gillmore, Julian D; Kalopissis, Athina D; Bellotti, Vittorio
Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils.
2011-01-01 Giorgetti, Sofia; Raimondi, Sara; Pagano, K; Relini, A; Bucciantini, M; Corazza, A; Fogolari, F; Codutti, L; Salmona, M; Mangione, Palma; Colombo, Lino; De Luigi, A; Porcari, Riccardo; Gliozzi, A; Stefani, M; Esposito, G; Bellotti, Vittorio; Stoppini, Monica
Folding and fibrillogenesis: clues from beta2-microglobulin.
2010-01-01 Rennella, E; Corazza, A; Giorgetti, Sofia; Fogolari, F; Viglino, P; Porcari, Riccardo; Verga, L; Stoppini, Monica; Bellotti, Vittorio; Esposito, G.
Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin.
2012-01-01 Valleix, S; Gillmore, Jd; Bridoux, F; Mangione, Palma; Dogan, A; Nedelec, B; Boimard, M; Touchard, G; Goujon, Jm; Lacombe, C; Lozeron, P; Adams, D; Lacroix, C; Maisonobe, T; Planté Bordeneuve, V; Vrana, Ja; Theis, Jd; Giorgetti, Sofia; Porcari, Riccardo; Ricagno, S; Bolognesi, M; Stoppini, Monica; Delpech, M; Pepys, Mb; Hawkins, Pn; Bellotti, Vittorio
Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel.
2017-01-01 Verona, Guglielmo; Mangione, Palma; Raimondi, Sara; Giorgetti, Sofia; Faravelli, Giulia; Porcari, Riccardo; Corazza, A; Gillmore, Jd; Hawkins, Pn; Pepys, Mb; Taylor, Gw; Bellotti, Vittorio
Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro
2016-01-01 Ozawa, Daisaku; Nomura, Ryo; Mangione, Palma; Hasegawa, Kazuhiro; Okoshi, Tadakazu; Porcari, Riccardo; Bellotti, Vittorio; Naiki, Hironobu
Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
2016-01-01 Camilloni, Carlo; Sala, Benedetta Maria; Sormanni, Pietro; Porcari, Riccardo; Corazza, Alessandra; De Rosa, Matteo; Zanini, Stefano; Barbiroli, Alberto; Esposito, Gennaro; Bolognesi, Martino; Bellotti, Vittorio; Vendruscolo, Michele; Ricagno, Stefano
Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin.
2013-01-01 Mangione, Palma; Esposito, G; Relini, A; Raimondi, Sara; Porcari, Riccardo; Giorgetti, Sofia; Corazza, A; Fogolari, F; Penco, A; Goto, Y; Lee, Yh; Yagi, H; Cecconi, C; Naqvi, Mm; Gillmore, Jd; Hawkins, Pn; Chiti, F; Rolandi, R; Taylor, Gw; Pepys, Mb; Stoppini, Monica; Bellotti, Vittorio
The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein.
2015-01-01 Porcari, Riccardo; Proukakis, C; Waudby, Ca; Bolognesi, B; Mangione, Palma; Paton, Jf; Mullin, S; Cabrita, Ld; Penco, A; Relini, A; Verona, Guglielmo; Vendruscolo, M; Stoppini, Monica; Tartaglia, Gg; Camilloni, C; Christodoulou, J; Schapira, Ah; Bellotti, Vittorio
The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies
2016-01-01 Leri, Manuela; Nosi, Daniele; Natalello, Antonino; Porcari, Riccardo; Ramazzotti, Matteo; Chiti, Fabrizio; Bellotti, Vittorio; Doglia, Silvia Maria; Stefani, Massimo; Bucciantini, Monica
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis | 1-gen-2015 | Marcoux, Julien; Mangione, Palma; Porcari, Riccardo; Degiacomi, Matteo T.; Verona, Guglielmo; Taylor, Graham W; Giorgetti, Sofia; Raimondi, Sara; Sanglier Cianférani, Sarah; Benesch, Justin Lp; Cecconi, Ciro; Naqvi, Mohsin M.; Gillmore, Julian D.; Hawkins, Philip N.; Stoppini, Monica; Robinson, Carol V.; Pepys, Mark B.; Bellotti, Vittorio | |
| A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo | 1-gen-2017 | Raimondi, Sara; Porcari, Riccardo; Mangione, Palma; Verona, Guglielmo; Marcoux, Julien; Giorgetti, Sofia; Taylor, Graham W.; Ellmerich, Stephan; Ballico, Maurizio; Zanini, Stefano; Pardon, Els; Al Shawi, Raya; Simons, J. Paul; Corazza, Alessandra; Fogolari, Federico; Leri, Manuela; Stefani, Massimo; Bucciantini, Monica; Gillmore, Julian D.; Hawkins, Philip N.; Valli, Maurizia; Stoppini, Monica; Robinson, Carol V.; Steyaert, Jan; Esposito, Gennaro; Bellotti, Vittorio | |
| Antiamyloidogenic and proamyloidogenic chaperone effects of C-reactive protein and serum amyloid P component | 1-gen-2017 | Ozawa, Daisaku; Nomura, Ryo; Mangione, Palma; Hasegawa, Kazuhiro; Okoshi, Tadakazu; Porcari, Riccardo; Bellotti, Vittorio; Naiki, Hironobu | |
| C. elegans expressing human beta2-microglobulin: a novel model for studying the relationship between the molecular assembly and the toxic phenotype. | 1-gen-2012 | L., Diomede; Soria, Cristina; M., Romeo; Giorgetti, Sofia; Marchese, Loredana; Mangione, Palma; Porcari, Riccardo; Zorzoli, Irene; M., Salmona; Bellotti, Vittorio; Stoppini, Monica | |
| Co-fibrillogenesis of Wild-type and D76N β2-Microglobulin: THE CRUCIAL ROLE OF FIBRILLAR SEEDS | 1-gen-2016 | Natalello, Antonino; Mangione, Palma; Giorgetti, Sofia; Porcari, Riccardo; Marchese, Loredana; Zorzoli, Irene; Relini, Annalisa; Ami, Diletta; Faravelli, Giulia; Valli, Maurizia; Stoppini, Monica; Doglia, Silvia M; Bellotti, Vittorio; Raimondi, Sara | |
| Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity | 1-gen-2018 | Le Marchand, Tanguy; De Rosa, Matteo; Salvi, Nicola; Sala, Benedetta Maria; Andreas, Loren B.; Barbet-Massin, Emeline; Sormanni, Pietro; Barbiroli, Alberto; Porcari, Riccardo; Sousa Mota, Cristiano; De Sanctis, Daniele; Bolognesi, Martino; Emsley, Lyndon; Bellotti, Vittorio; Blackledge, Martin; Camilloni, Carlo; Pintacuda, Guido; Ricagno, Stefano | |
| D25V apolipoprotein C-III variant causes dominant hereditary systemic amyloidosis and confers cardiovascular protective lipoprotein profile | 1-gen-2016 | Valleix, Sophie; Verona, Guglielmo; Jourde Chiche, Noémie; Nédelec, Brigitte; Mangione, Palma; Bridoux, Frank; Mangé, Alain; Dogan, Ahmet; Goujon, Jean Michel; Lhomme, Marie; Dauteuille, Carolane; Chabert, Michèle; Porcari, Riccardo; Waudby, Christopher A; Relini, Annalisa; Talmud, Philippa J; Kovrov, Oleg; Olivecrona, Gunilla; Stoppini, Monica; Christodoulou, John; Hawkins, Philip N; Grateau, Gilles; Delpech, Marc; Kontush, Anatol; Gillmore, Julian D; Kalopissis, Athina D; Bellotti, Vittorio | |
| Effect of tetracyclines on the dynamics of formation and destructuration of {beta}2-microglobulin amyloid fibrils. | 1-gen-2011 | Giorgetti, Sofia; Raimondi, Sara; Pagano, K; Relini, A; Bucciantini, M; Corazza, A; Fogolari, F; Codutti, L; Salmona, M; Mangione, Palma; Colombo, Lino; De Luigi, A; Porcari, Riccardo; Gliozzi, A; Stefani, M; Esposito, G; Bellotti, Vittorio; Stoppini, Monica | |
| Folding and fibrillogenesis: clues from beta2-microglobulin. | 1-gen-2010 | Rennella, E; Corazza, A; Giorgetti, Sofia; Fogolari, F; Viglino, P; Porcari, Riccardo; Verga, L; Stoppini, Monica; Bellotti, Vittorio; Esposito, G. | |
| Hereditary systemic amyloidosis due to Asp76Asn variant β2-microglobulin. | 1-gen-2012 | Valleix, S; Gillmore, Jd; Bridoux, F; Mangione, Palma; Dogan, A; Nedelec, B; Boimard, M; Touchard, G; Goujon, Jm; Lacombe, C; Lozeron, P; Adams, D; Lacroix, C; Maisonobe, T; Planté Bordeneuve, V; Vrana, Ja; Theis, Jd; Giorgetti, Sofia; Porcari, Riccardo; Ricagno, S; Bolognesi, M; Stoppini, Monica; Delpech, M; Pepys, Mb; Hawkins, Pn; Bellotti, Vittorio | |
| Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel. | 1-gen-2017 | Verona, Guglielmo; Mangione, Palma; Raimondi, Sara; Giorgetti, Sofia; Faravelli, Giulia; Porcari, Riccardo; Corazza, A; Gillmore, Jd; Hawkins, Pn; Pepys, Mb; Taylor, Gw; Bellotti, Vittorio | |
| Multifaceted anti-amyloidogenic and pro-amyloidogenic effects of C-reactive protein and serum amyloid P component in vitro | 1-gen-2016 | Ozawa, Daisaku; Nomura, Ryo; Mangione, Palma; Hasegawa, Kazuhiro; Okoshi, Tadakazu; Porcari, Riccardo; Bellotti, Vittorio; Naiki, Hironobu | |
| Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability | 1-gen-2016 | Camilloni, Carlo; Sala, Benedetta Maria; Sormanni, Pietro; Porcari, Riccardo; Corazza, Alessandra; De Rosa, Matteo; Zanini, Stefano; Barbiroli, Alberto; Esposito, Gennaro; Bolognesi, Martino; Bellotti, Vittorio; Vendruscolo, Michele; Ricagno, Stefano | |
| Structure, folding dynamics and amyloidogenesis of Asp76Asn β2-microglobulin: roles of shear flow, hydrophobic surfaces and α crystallin. | 1-gen-2013 | Mangione, Palma; Esposito, G; Relini, A; Raimondi, Sara; Porcari, Riccardo; Giorgetti, Sofia; Corazza, A; Fogolari, F; Penco, A; Goto, Y; Lee, Yh; Yagi, H; Cecconi, C; Naqvi, Mm; Gillmore, Jd; Hawkins, Pn; Chiti, F; Rolandi, R; Taylor, Gw; Pepys, Mb; Stoppini, Monica; Bellotti, Vittorio | |
| The H50Q mutation induces a tenfold decrease in the solubility of α-synuclein. | 1-gen-2015 | Porcari, Riccardo; Proukakis, C; Waudby, Ca; Bolognesi, B; Mangione, Palma; Paton, Jf; Mullin, S; Cabrita, Ld; Penco, A; Relini, A; Verona, Guglielmo; Vendruscolo, M; Stoppini, Monica; Tartaglia, Gg; Camilloni, C; Christodoulou, J; Schapira, Ah; Bellotti, Vittorio | |
| The polyphenol Oleuropein aglycone hinders the growth of toxic transthyretin amyloid assemblies | 1-gen-2016 | Leri, Manuela; Nosi, Daniele; Natalello, Antonino; Porcari, Riccardo; Ramazzotti, Matteo; Chiti, Fabrizio; Bellotti, Vittorio; Doglia, Silvia Maria; Stefani, Massimo; Bucciantini, Monica |