COLOMBO, GIORGIO
COLOMBO, GIORGIO
DIPARTIMENTO DI CHIMICA
2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors
2009-01-01 Bracci, Antonio; Colombo, Giorgio; Ronchetti, Fiamma; Compostella, Federica
3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues
2013-01-01 Zhao, Huiping; Moroni, Elisabetta; Yan, Bin; Colombo, Giorgio; Blagg, Brian S. J.
A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers
2018-01-01 Pavlin, Matic; Spinello, Angelo; Pennati, Marzia; Zaffaroni, Nadia; Gobbi, Silvia; Bisi, Alessandra; Colombo, Giorgio; Magistrato, Alessandra
A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators
2005-01-01 Fogolari, F; Tosatto, Sce; Colombo, G
A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains
2005-01-01 Colombo, G; Meli, M; Canada, J; Asensio, Jl; Jimenez-Barbero, J
A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes
2022-01-01 Scietti, Luigi; Moroni, Elisabetta; Mattoteia, Daiana; Fumagalli, Marco; De Marco, Matteo; Negro, Lisa; Chiapparino, Antonella; Serapian, Stefano A.; De Giorgi, Francesca; Faravelli, Silvia; Colombo, Giorgio; Forneris, Federico
A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins
2013-01-01 Meli, Massimiliano; Colombo, Giorgio
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions
2018-01-01 Rinaldi, Silvia; Assimon, Victoria A.; Young, Zapporah T.; Morra, Giulia; Shao, Hao; Taylor, Isabelle R.; Gestwicki, Jason E.; Colombo, Giorgio
A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation
2008-01-01 Esteras-Chopo, Alexandra; Morra, Giulia; Moroni, Elisabetta; Serrano, Luis; de la Paz Manuela, Lopez; Colombo, Giorgio
A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35
2011-01-01 Nasica-Labouze, Jessica; Meli, Massimiliano; Derreumaux, Philippe; Colombo, Giorgio; Rousseau, Normand
A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro
2017-01-01 Maggi, Maristella; Mittelman Steven, D.; Parmentier Jean, Hugues; Colombo, Giorgio; Meli, Massimiliano; Whitmire Jeannette, Marie; Merrell D., Scott; Whitelegge, Julian; Scotti, Claudia
A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen
2013-01-01 Lascaux, Patricia; Peri, Claudio; Ferrer-Navarro, Mario; Gourlay Louise, J; Gori, Alessandro; Conchillo-Sole, Oscar; Rinchai, Darawan; Lertmemongkolchai, Ganjana; Longhi, Renato; Daura, Xavier; Colombo, Giorgio; Bolognesi, Martino
Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm
2007-01-01 Bazzoli, A; Colombo, G; Tettamanzi, A
Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands
2015-01-01 Sattin, Sara; Tao, Jiahui; Vettoretti, Gerolamo; Moroni, Elisabetta; Pennati, Marzia; Lopergolo, Alessia; Morelli, Laura; Bugatti, Antonella; Zuehlke, Abbey; Moses, Mike; Prince, Thomas; Kijima, Toshiki; Beebe, Kristin; Rusnati, Marco; Neckers, Len; Zaffaroni, Nadia; Agard David, A; Bernardi, Anna; Colombo, Giorgio
ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells
2019-01-01 Jimenez-Pascual, A.; Hale, J. S.; Kordowski, A.; Pugh, J.; Silver, D. J.; Bayik, D.; Roversi, G.; Alban, T. J.; Rao, S.; Chen, R.; Mcintyre, T. M.; Colombo, G.; Taraboletti, G.; Holmberg, K. O.; Forsberg-Nilsson, K.; Lathia, J. D.; Siebzehnrubl, F. A.
AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells
2006-01-01 Pennati, M; Meli, M; Curto, M; Daidone, Mg; Plescia, J; Toba, S; Altieri, Dc; Zaffaroni, N; Colombo, G
All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures
2004-01-01 De Mori, Gms; Micheletti, C; Colombo, G
Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design
2018-01-01 Ferraro, M; D'Annessa, I; Moroni, E; Morra, G; Paladino, A; Rinaldi, S; Compostella, F; Colombo, G
Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90
2016-01-01 Rehn, Alexandra; Moroni, Elisabetta; Zierer Bettina, K; Tippel, Franziska; Morra, Giulia; John, Christine; Richter, Klaus; Colombo, Giorgio; Buchner, Johannes
AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity
2022-01-01 Perna, Laura; Castelli, Matteo; Frasnetti, Elena; Romano, Lisa E L; Colombo, Giorgio; Prodromou, Chrisostomos; Chapple, J Paul
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| 2 `-O-Alkyl Derivatives and 5 `-Analogues of 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) as Potential Hsp90 Inhibitors | 1-gen-2009 | Bracci, Antonio; Colombo, Giorgio; Ronchetti, Fiamma; Compostella, Federica | |
| 3D-QSAR-Assisted Design, Synthesis, and Evaluation of Novobiocin Analogues | 1-gen-2013 | Zhao, Huiping; Moroni, Elisabetta; Yan, Bin; Colombo, Giorgio; Blagg, Brian S. J. | |
| A Computational Assay of Estrogen Receptor alpha Antagonists Reveals the Key Common Structural Traits of Drugs Effectively Fighting Refractory Breast Cancers | 1-gen-2018 | Pavlin, Matic; Spinello, Angelo; Pennati, Marzia; Zaffaroni, Nadia; Gobbi, Silvia; Bisi, Alessandra; Colombo, Giorgio; Magistrato, Alessandra | |
| A decoy set for the thermostable subdomain from chicken villin headpiece, comparison of different free energy estimators | 1-gen-2005 | Fogolari, F; Tosatto, Sce; Colombo, G | |
| A dynamic perspective on the molecular recognition of chitooligosaccharide ligands by hevein domains | 1-gen-2005 | Colombo, G; Meli, M; Canada, J; Asensio, Jl; Jimenez-Barbero, J | |
| A Fe2+-dependent self-inhibited state influences the druggability of human collagen lysyl hydroxylase (LH/PLOD) enzymes | 1-gen-2022 | Scietti, Luigi; Moroni, Elisabetta; Mattoteia, Daiana; Fumagalli, Marco; De Marco, Matteo; Negro, Lisa; Chiapparino, Antonella; Serapian, Stefano A.; De Giorgi, Francesca; Faravelli, Silvia; Colombo, Giorgio; Forneris, Federico | |
| A Hamiltonian Replica Exchange Molecular Dynamics (MD) Method for the Study of Folding, Based on the Analysis of the Stabilization Determinants of Proteins | 1-gen-2013 | Meli, Massimiliano; Colombo, Giorgio | |
| A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions | 1-gen-2018 | Rinaldi, Silvia; Assimon, Victoria A.; Young, Zapporah T.; Morra, Giulia; Shao, Hao; Taylor, Isabelle R.; Gestwicki, Jason E.; Colombo, Giorgio | |
| A Molecular Dynamics Study of the Interaction of D-Peptide Amyloid Inhibitors with Their Target Sequence Reveals a Potential Inhibitory Pharmacophore Conformation | 1-gen-2008 | Esteras-Chopo, Alexandra; Morra, Giulia; Moroni, Elisabetta; Serrano, Luis; de la Paz Manuela, Lopez; Colombo, Giorgio | |
| A Multiscale Approach to Characterize the Early Aggregation Steps of the Amyloid-Forming Peptide GNNQQNY from the Yeast Prion Sup-35 | 1-gen-2011 | Nasica-Labouze, Jessica; Meli, Massimiliano; Derreumaux, Philippe; Colombo, Giorgio; Rousseau, Normand | |
| A protease-resistant Escherichia coli asparaginase with outstanding stability and enhanced anti-leukaemic activity in vitro | 1-gen-2017 | Maggi, Maristella; Mittelman Steven, D.; Parmentier Jean, Hugues; Colombo, Giorgio; Meli, Massimiliano; Whitmire Jeannette, Marie; Merrell D., Scott; Whitelegge, Julian; Scotti, Claudia | |
| A Structure-Based Strategy for Epitope Discovery in Burkholderia pseudomallei OppA Antigen | 1-gen-2013 | Lascaux, Patricia; Peri, Claudio; Ferrer-Navarro, Mario; Gourlay Louise, J; Gori, Alessandro; Conchillo-Sole, Oscar; Rinchai, Darawan; Lertmemongkolchai, Ganjana; Longhi, Renato; Daura, Xavier; Colombo, Giorgio; Bolognesi, Martino | |
| Ab initio protein structure prediction with a dipeptide-assembly evolutionary algorithm | 1-gen-2007 | Bazzoli, A; Colombo, G; Tettamanzi, A | |
| Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands | 1-gen-2015 | Sattin, Sara; Tao, Jiahui; Vettoretti, Gerolamo; Moroni, Elisabetta; Pennati, Marzia; Lopergolo, Alessia; Morelli, Laura; Bugatti, Antonella; Zuehlke, Abbey; Moses, Mike; Prince, Thomas; Kijima, Toshiki; Beebe, Kristin; Rusnati, Marco; Neckers, Len; Zaffaroni, Nadia; Agard David, A; Bernardi, Anna; Colombo, Giorgio | |
| ADAMDEC1 maintains a growth factor signaling loop in cancer stem cells | 1-gen-2019 | Jimenez-Pascual, A.; Hale, J. S.; Kordowski, A.; Pugh, J.; Silver, D. J.; Bayik, D.; Roversi, G.; Alban, T. J.; Rao, S.; Chen, R.; Mcintyre, T. M.; Colombo, G.; Taraboletti, G.; Holmberg, K. O.; Forsberg-Nilsson, K.; Lathia, J. D.; Siebzehnrubl, F. A. | |
| AICAR: A rational identified small molecule targeting Hsp90 chaperone function in cancer cells | 1-gen-2006 | Pennati, M; Meli, M; Curto, M; Daidone, Mg; Plescia, J; Toba, S; Altieri, Dc; Zaffaroni, N; Colombo, G | |
| All-atom folding simulations of the villin headpiece from stochastically selected coarse-grained structures | 1-gen-2004 | De Mori, Gms; Micheletti, C; Colombo, G | |
| Allosteric modulators of Hsp90 and Hsp70: Dynamics meets Function through Structure-Based Drug Design | 1-gen-2018 | Ferraro, M; D'Annessa, I; Moroni, E; Morra, G; Paladino, A; Rinaldi, S; Compostella, F; Colombo, G | |
| Allosteric Regulation Points Control the Conformational Dynamics of the Molecular Chaperone Hsp90 | 1-gen-2016 | Rehn, Alexandra; Moroni, Elisabetta; Zierer Bettina, K; Tippel, Franziska; Morra, Giulia; John, Christine; Richter, Klaus; Colombo, Giorgio; Buchner, Johannes | |
| AlphaFold predicted structure of the Hsp90-like domains of the neurodegeneration linked protein sacsin reveals key residues for ATPase activity | 1-gen-2022 | Perna, Laura; Castelli, Matteo; Frasnetti, Elena; Romano, Lisa E L; Colombo, Giorgio; Prodromou, Chrisostomos; Chapple, J Paul |