Cell activation and death (apoptosis) induced by IL-2: ultrastructural evidence.

Capelli, E; Barni, S.; Vaccarone, R; Fortis, C; Nano, R

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Peripheral blood cells of cancer patients with advanced renal carcinoma and treated with interleukin-2 by intravenous application were studied by electron microscopy at different intervals from the beginning of rIL-2 administration. Morphofunctional modifications of lymphocytes, circulating hystiocytes containing phagocitated bodies and polimorphonucleated cells undergoing phagocytosis were observed with a time dependent increase of altered cells. The analysis of blood cells cultured in the presence of recombinant IL-2 confirmed the in vivo results. Our data suggest that IL-2 induces apoptotic phenomena in the peripheral blood cells of treated patients.

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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/101621

Titolo:	Cell activation and death (apoptosis) induced by IL-2: ultrastructural evidence.
Autori interni:	CAPELLI, ENRICA BARNI, SERGIO VACCARONE, RITA NANO, ROSANNA
Data di pubblicazione:	1996
Rivista:	ANTICANCER RESEARCH
Abstract:	Peripheral blood cells of cancer patients with advanced renal carcinoma and treated with interleukin-2 by intravenous application were studied by electron microscopy at different intervals from the beginning of rIL-2 administration. Morphofunctional modifications of lymphocytes, circulating hystiocytes containing phagocitated bodies and polimorphonucleated cells undergoing phagocytosis were observed with a time dependent increase of altered cells. The analysis of blood cells cultured in the presence of recombinant IL-2 confirmed the in vivo results. Our data suggest that IL-2 induces apoptotic phenomena in the peripheral blood cells of treated patients.
Handle:	http://hdl.handle.net/11571/101621
Appare nelle tipologie:	1.1 Articolo in rivista

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