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EnglishThe purpose of this research was to investigate 5-methylpyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. The best modulation of protein release was achieved by cross-linking performed at pH 6.5. Good bioadhesion properties were maintained even with high cross-linking degrees. By setting suitable tripolyphosphate cross-linking conditions for MPC films, one can control protein release without affecting bioadhesion.
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| Titolo: | 5-METHYL-PYRROLIDINONE CHITOSAN FILMS AS CARRIRERS FOR BUCCAL ADMINISTRATION OF PROTEINS |
| Autori: | |
| Data di pubblicazione: | 2006 |
| Rivista: | |
| Abstract: | The purpose of this research was to investigate 5-methylpyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. The best modulation of protein release was achieved by cross-linking performed at pH 6.5. Good bioadhesion properties were maintained even with high cross-linking degrees. By setting suitable tripolyphosphate cross-linking conditions for MPC films, one can control protein release without affecting bioadhesion. |
| Handle: | http://hdl.handle.net/11571/102900 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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