CINECA IRIS Institutional Research Information System
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishThe purpose of this research was to investigate 5-methylpyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. The best modulation of protein release was achieved by cross-linking performed at pH 6.5. Good bioadhesion properties were maintained even with high cross-linking degrees. By setting suitable tripolyphosphate cross-linking conditions for MPC films, one can control protein release without affecting bioadhesion.
Scheda prodotto non validato
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo
http://hdl.handle.net/11571/102900| Titolo: | 5-METHYL-PYRROLIDINONE CHITOSAN FILMS AS CARRIRERS FOR BUCCAL ADMINISTRATION OF PROTEINS |
| Autori interni: | COLONNA, CLAUDIA GENTA, IDA PERUGINI, PAOLA PAVANETTO, FRANCA MODENA, TIZIANA VALLI, MAURIZIA CONTI, BICE |
| Data di pubblicazione: | 2006 |
| Rivista: | AAPS PHARMSCITECH |
| Abstract: | The purpose of this research was to investigate 5-methylpyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. The best modulation of protein release was achieved by cross-linking performed at pH 6.5. Good bioadhesion properties were maintained even with high cross-linking degrees. By setting suitable tripolyphosphate cross-linking conditions for MPC films, one can control protein release without affecting bioadhesion. |
| Handle: | http://hdl.handle.net/11571/102900 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
File in questo prodotto:
Copyright © 2017