The purpose of this research was to investigate 5-methylpyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. The best modulation of protein release was achieved by cross-linking performed at pH 6.5. Good bioadhesion properties were maintained even with high cross-linking degrees. By setting suitable tripolyphosphate cross-linking conditions for MPC films, one can control protein release without affecting bioadhesion.
5-METHYL-PYRROLIDINONE CHITOSAN FILMS AS CARRIRERS FOR BUCCAL ADMINISTRATION OF PROTEINS
COLONNA, CLAUDIA;GENTA, IDA;PERUGINI, PAOLA;PAVANETTO, FRANCA;MODENA, TIZIANA;VALLI, MAURIZIA;CONTI, BICE
2006-01-01
Abstract
The purpose of this research was to investigate 5-methylpyrrolidinone chitosan (MPC) films as carriers for buccal delivery of protein drugs. The best modulation of protein release was achieved by cross-linking performed at pH 6.5. Good bioadhesion properties were maintained even with high cross-linking degrees. By setting suitable tripolyphosphate cross-linking conditions for MPC films, one can control protein release without affecting bioadhesion.File in questo prodotto:
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