Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes.

PEDRALI NOY, G. C.; Dalprà, L.; Pedrini, A. M.; Ciarrocchi, G.; Giulotto, Elena; Nuzzo, F.; Falaschi, A.; Spadari, S.

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The stimulation of human lymphocytes with phytohaemoagglutinin induces the appearance or increase of several enzymes of DNA metabolism [Pedrini etal., Biochem. Biophys. Res. Comm., 47:1221(1972)]. With long times of stimulation, two phenomena are observed; an increase in the levels of DNA polymerase, of a DNase acting on single-stranded DNA, and of an endonuclease, occurring between the third and fourth day, in parallel with a wave of DNA synthesis;a second wave of increase of the same enzymes and of DNA ligase,occurring between the fifth and eight day when the DNA replication rate, as measured by thymidine-pulses, has decreased to values close to the background.

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Titolo:	Evidence for two waves of induction of DNA enzymes in stimulated human lymphocytes.
Autori:	PEDRALI NOY G. C. DALPRÀ L. PEDRINI A. M. CIARROCCHI G. GIULOTTO, ELENA NUZZO F. FALASCHI A. SPADARI S. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1974
Rivista:	NUCLEIC ACIDS RESEARCH
Abstract:	The stimulation of human lymphocytes with phytohaemoagglutinin induces the appearance or increase of several enzymes of DNA metabolism [Pedrini etal., Biochem. Biophys. Res. Comm., 47:1221(1972)]. With long times of stimulation, two phenomena are observed; an increase in the levels of DNA polymerase, of a DNase acting on single-stranded DNA, and of an endonuclease, occurring between the third and fourth day, in parallel with a wave of DNA synthesis;a second wave of increase of the same enzymes and of DNA ligase,occurring between the fifth and eight day when the DNA replication rate, as measured by thymidine-pulses, has decreased to values close to the background.
Handle:	http://hdl.handle.net/11571/106993
Appare nelle tipologie:	1.1 Articolo in rivista

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