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EnglishTwo gastric cancer cell lines, AKG and GK2, were established from a pleural and an ascitic effusion, respectively. GK2 cells have a pseudodiploid karyotype with an add(6)(q27) chromosome in all metaphases examined. The karyotype of AKG cells is highly rearranged: FISH analysis with painting probes has shown that DNA sequences derived from single chromosomes are scattered on several (as many as eight) markers. In this cell line, the C-MYC and the K-RAS oncogenes are amplified. The organization and the copy number of the C-MYC-amplified units are different from the K-RAS units, suggesting that the two oncogenes were amplified independently. The presence of a few marker chromosomes carrying both C-MYC and K-RAS could be due to translocation events that followed the amplification.
Different genome organization in two new cell lines established from human gastric carcinoma. / BERTONI L.; ZOLI W.; MUCCIOLO E.; RICOTTI L.; NERGADZE S.; AMADORI D.; E. GIULOTTO. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 105:2(1998), pp. 152-159.
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| Titolo: | Different genome organization in two new cell lines established from human gastric carcinoma. |
| Autori: | |
| Data di pubblicazione: | 1998 |
| Rivista: | |
| Citazione: | Different genome organization in two new cell lines established from human gastric carcinoma. / BERTONI L.; ZOLI W.; MUCCIOLO E.; RICOTTI L.; NERGADZE S.; AMADORI D.; E. GIULOTTO. - In: CANCER GENETICS AND CYTOGENETICS. - ISSN 0165-4608. - STAMPA. - 105:2(1998), pp. 152-159. |
| Abstract: | Two gastric cancer cell lines, AKG and GK2, were established from a pleural and an ascitic effusion, respectively. GK2 cells have a pseudodiploid karyotype with an add(6)(q27) chromosome in all metaphases examined. The karyotype of AKG cells is highly rearranged: FISH analysis with painting probes has shown that DNA sequences derived from single chromosomes are scattered on several (as many as eight) markers. In this cell line, the C-MYC and the K-RAS oncogenes are amplified. The organization and the copy number of the C-MYC-amplified units are different from the K-RAS units, suggesting that the two oncogenes were amplified independently. The presence of a few marker chromosomes carrying both C-MYC and K-RAS could be due to translocation events that followed the amplification. |
| Handle: | http://hdl.handle.net/11571/107116 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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