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EnglishMonosomy 7 (-7) and deletion 7q \del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations \+/- other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 +/- other compared with del(7q) +/- other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) +/- other compared with -7 +/- other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML \t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or + 21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification.
Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia:An international retrospective study / HASLE H; ALONZO TA; AUVRIGNON A; BEHAR C; CHANG M; CREUTZIG U; FISCHER A; FORESTIER E; FYNN A; HAAS OA; HARBOTT J; HARRISON CJ; HEEREMA NA; VAN DEN HEUVEL-EIBRINK MM; KASPERS GJL; F. LOCATELLI; NOELLKE P; POLYCHRONOPOULOU S; RAVINDRANATH Y; RAZZOUK B; REINHARDT D; SAVVA NN; STARK B; SUCIU S; TSUKIMOTO I; WEBB DK; WOJCIK D; WOODS WG; ZIMMERMANN M; NIEMEYER CM; RAIMONDI SC. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 109:11(2007), pp. 4641-4647.
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| Titolo: | Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia:An international retrospective study |
| Autori: | |
| Data di pubblicazione: | 2007 |
| Rivista: | |
| Citazione: | Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia:An international retrospective study / HASLE H; ALONZO TA; AUVRIGNON A; BEHAR C; CHANG M; CREUTZIG U; FISCHER A; FORESTIER E; FYNN A; HAAS OA; HARBOTT J; HARRISON CJ; HEEREMA NA; VAN DEN HEUVEL-EIBRINK MM; KASPERS GJL; F. LOCATELLI; NOELLKE P; POLYCHRONOPOULOU S; RAVINDRANATH Y; RAZZOUK B; REINHARDT D; SAVVA NN; STARK B; SUCIU S; TSUKIMOTO I; WEBB DK; WOJCIK D; WOODS WG; ZIMMERMANN M; NIEMEYER CM; RAIMONDI SC. - In: BLOOD. - ISSN 0006-4971. - STAMPA. - 109:11(2007), pp. 4641-4647. |
| Abstract: | Monosomy 7 (-7) and deletion 7q \del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations \+/- other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 +/- other compared with del(7q) +/- other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) +/- other compared with -7 +/- other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML \t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or + 21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future risk-group stratification. |
| Handle: | http://hdl.handle.net/11571/108803 |
| Appare nelle tipologie: | 1.1 Articolo in rivista |
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