A new method for preparation of chitosan microspheres loaded with an hydrofobic drug, ketoprofen, was developed. It is an emulsification/solvent evaporation process carried out in mild conditions and particularly useful for thermally sensitive drugs. This method should be additionally combined wit chemical and physical cross-linking in order to modulate drug release. Physical cross-linking was carried out by dry heating chitosan miscrospheres at fixed temperature and for different times. Glutaraldheyde at different concentrations was used as chemical cross-linking agent using microspheres constituted by different theoretical ketoprofen/chitosan ratios (1:2, 1:4, 1:6 w/w). Chitosan microspheres were morphologically characterized for shape, surface characteristics and size distribution.; chitosan/ketoprofen interactions inside the microspheres were investigated by DSC and powder X-ray difractometry. Ketoprofen contents inside the microspheres and in vitro drug release profiles were also determined.

A multiple emulsion method to entrap a lipophilic compound into chitosan microspheres

GENTA, IDA
;
PERUGINI P.;CONTI B.;
1997-01-01

Abstract

A new method for preparation of chitosan microspheres loaded with an hydrofobic drug, ketoprofen, was developed. It is an emulsification/solvent evaporation process carried out in mild conditions and particularly useful for thermally sensitive drugs. This method should be additionally combined wit chemical and physical cross-linking in order to modulate drug release. Physical cross-linking was carried out by dry heating chitosan miscrospheres at fixed temperature and for different times. Glutaraldheyde at different concentrations was used as chemical cross-linking agent using microspheres constituted by different theoretical ketoprofen/chitosan ratios (1:2, 1:4, 1:6 w/w). Chitosan microspheres were morphologically characterized for shape, surface characteristics and size distribution.; chitosan/ketoprofen interactions inside the microspheres were investigated by DSC and powder X-ray difractometry. Ketoprofen contents inside the microspheres and in vitro drug release profiles were also determined.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/109389
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