GV150526A is a novel 2-carboxyindole derivative, recently synthesized by GlaxoWellcome, which is used in treatment or prevention of CNS disorders resulting from neurotoxic damage. It has been prepared in three forms, F1, F2 and F3, having significantly different hydration/dehydration behavior and/or diffraction patterns. Here, we extend the thermal analysis of these polymorphs above 200°C, where all forms are fully dehydrated and the main thermal phenomena are decomposition and melting. Simultaneous TG/DSC measurements have been repeated in wet and dry nitrogen atmospheres over a wide range of heating rates. Form F3 displays a qualitatively different behavior relative to F1 and F2. This fact is interpreted as an evidence of a mechanism of decomposition which sets F3 apart from F1 and F2. The thermal data are summarized by simple heuristic equations and few apparent enthalpies.
Thermal decomposition and melting of a new carboxyindole derivative
MARINI, AMEDEO;BERBENNI, VITTORIO;BRUNI, GIOVANNA;
2002-01-01
Abstract
GV150526A is a novel 2-carboxyindole derivative, recently synthesized by GlaxoWellcome, which is used in treatment or prevention of CNS disorders resulting from neurotoxic damage. It has been prepared in three forms, F1, F2 and F3, having significantly different hydration/dehydration behavior and/or diffraction patterns. Here, we extend the thermal analysis of these polymorphs above 200°C, where all forms are fully dehydrated and the main thermal phenomena are decomposition and melting. Simultaneous TG/DSC measurements have been repeated in wet and dry nitrogen atmospheres over a wide range of heating rates. Form F3 displays a qualitatively different behavior relative to F1 and F2. This fact is interpreted as an evidence of a mechanism of decomposition which sets F3 apart from F1 and F2. The thermal data are summarized by simple heuristic equations and few apparent enthalpies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.