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A conceptually new light-up nucleic acid fluorescent probe resulting from the conjugation of a coumarin to a naphthalene diimide exhibits a single wavelength emission at 498 nm when free in solution and an additional red/NIR emission when bound to G-quadruplex DNA. The light-up response centred at 666 nm is highly specific for quadruplex DNA when compared to duplex DNA or to RNA quadruplexes.

Red/NIR G-Quadruplex Sensing, Harvesting Blue Light by a Coumarin-Naphthalene Diimide Dyad

ZUFFO, MICHELA;DORIA, FILIPPO;FRECCERO, MAURO
2015-01-01

Abstract

A conceptually new light-up nucleic acid fluorescent probe resulting from the conjugation of a coumarin to a naphthalene diimide exhibits a single wavelength emission at 498 nm when free in solution and an additional red/NIR emission when bound to G-quadruplex DNA. The light-up response centred at 666 nm is highly specific for quadruplex DNA when compared to duplex DNA or to RNA quadruplexes.
2015
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CHEMISTRY-A EUROPEAN JOURNAL
sì
WOS:000367185700010
2-s2.0-84948471209
Esperti anonimi
Inglese
Internazionale
ELETTRONICO
21
49
17596
17600
5
26463116
G-quadruplexes; dyes; fluorescent probes; naphthalene diimide; nucleic acids
sì
5
info:eu-repo/semantics/article
262
Zuffo, Michela; Doria, Filippo; Spalluto, Vincenzo; Ladame, Sylvain; Freccero, Mauro
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1106103
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