The synthetic pathway towards silyl-substituted nucleoside analogs is presented and relies upon the 1,3-dipolar cycloaddition of in situ generated nitrile oxide containing a representative silyl group. The subsequent synthetic elaborations do not damage this substituent allowing for the obtaining of the target compounds. This reliable methodology is prone to be adapted for the synthesis of silyl derivatives for several applications.
Paralipomena of the Isoxazoline Carbocyclic Nucleoside Analogs
QUADRELLI, PAOLO
2016-01-01
Abstract
The synthetic pathway towards silyl-substituted nucleoside analogs is presented and relies upon the 1,3-dipolar cycloaddition of in situ generated nitrile oxide containing a representative silyl group. The subsequent synthetic elaborations do not damage this substituent allowing for the obtaining of the target compounds. This reliable methodology is prone to be adapted for the synthesis of silyl derivatives for several applications.File in questo prodotto:
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