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The synthetic pathway towards silyl-substituted nucleoside analogs is presented and relies upon the 1,3-dipolar cycloaddition of in situ generated nitrile oxide containing a representative silyl group. The subsequent synthetic elaborations do not damage this substituent allowing for the obtaining of the target compounds. This reliable methodology is prone to be adapted for the synthesis of silyl derivatives for several applications.

Paralipomena of the Isoxazoline Carbocyclic Nucleoside Analogs

QUADRELLI, PAOLO
2016-01-01

Abstract

The synthetic pathway towards silyl-substituted nucleoside analogs is presented and relies upon the 1,3-dipolar cycloaddition of in situ generated nitrile oxide containing a representative silyl group. The subsequent synthetic elaborations do not damage this substituent allowing for the obtaining of the target compounds. This reliable methodology is prone to be adapted for the synthesis of silyl derivatives for several applications.
2016
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
CHEMISTRYSELECT
sì
2-s2.0-85041962699
Esperti anonimi
Inglese
Internazionale
STAMPA
1
1496
1502
7
Nitrile oxides, nitrosocarbonyl, nucleoside, silycon derivatives, organic synthesis
no
3
info:eu-repo/semantics/article
262
Savion, Marco; Bovio, Bruna; Quadrelli, Paolo
1 Contributo su Rivista::1.1 Articolo in rivista
none
1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1121985
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