Germ line LNK mutations rarely occur in familial MPNs and do not segregate with the disease phenotype. Our findings suggest that mutations in LNK, either germ line or acquired, may cooperate with acquired driver mutations in JAK2, CALR, or MPL to determine disease phenotype in MPNs.
LNK mutations in familial myeloproliferative neoplasms.
RUMI, ELISA;CAZZOLA, MARIO
2016-01-01
Abstract
Germ line LNK mutations rarely occur in familial MPNs and do not segregate with the disease phenotype. Our findings suggest that mutations in LNK, either germ line or acquired, may cooperate with acquired driver mutations in JAK2, CALR, or MPL to determine disease phenotype in MPNs.File in questo prodotto:
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