In this work, an o/w/o multiple emulsion technique was used to prepare hydrophobic drug loaded chitosan microsphers. Moreover, the influence of different viariables (acetic acid concentration and drug/polymer ratio) on microspheres morphology and drug content was evaluated. Two chitosans of different molecular weight and degree of deacetylation were used; ketoprofen, an anti-inflammatory drug, was chosen as model hydrophobic drug. The new pretaration method produced well-formed microspheres with very good yields. Acetic acid concentration influenced particle sizes and drug content of the microspheres. The highest drug encapsulation efficiency was achieved with the lowest theoretical drug/chitosan ratio.

Evaluation of process parameters involved in chitosan microsphere preparation by the O/W/O multiple emulsion method.

PAVANETTO, FRANCA;PERUGINI, PAOLA;CONTI, BICE;MODENA, TIZIANA;GENTA, IDA
1996-01-01

Abstract

In this work, an o/w/o multiple emulsion technique was used to prepare hydrophobic drug loaded chitosan microsphers. Moreover, the influence of different viariables (acetic acid concentration and drug/polymer ratio) on microspheres morphology and drug content was evaluated. Two chitosans of different molecular weight and degree of deacetylation were used; ketoprofen, an anti-inflammatory drug, was chosen as model hydrophobic drug. The new pretaration method produced well-formed microspheres with very good yields. Acetic acid concentration influenced particle sizes and drug content of the microspheres. The highest drug encapsulation efficiency was achieved with the lowest theoretical drug/chitosan ratio.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/115454
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