Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and finictional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.

Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

VALENTE, ENZA MARIA;
2005

Abstract

Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and finictional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/1180761
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