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Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and finictional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.

Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

VALENTE, ENZA MARIA;
2005-01-01

Abstract

Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and finictional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.
2005
Molecular Biology & Genetics considers all aspects of basic and applied genetics, including molecular genetics, prokaryotic and eukaryotic gene expression, mechanisms of mutagenesis, structure, function and regulation of genetic material. Also included are resources concerned with clinical genetics, patterns of inheritance, genetic cause, and screening and treatment of disease. Resources dealing specifically with developmentally regulated gene expression, or with signal transduction pathways that modulate gene expression at the cellular level are excluded and are covered in the Cell and Developmental Biology category.
The Neurology category covers resources concerned with the central and peripheral nervous system including the brain, spinal cord, nerves, and fluids. Coverage includes general and clinical neurology including neurosurgery, neuropsychiatry, neuropsychology, neurophysiology, neuroradiology, neuropediatrics, neuropathology, and neurobiology. Resources on cerebrovascular diseases, movement and spinal disorders, pain, dementia, headache, aphasiology, brain injury, paraplegia, stroke, and acupuncture are also included.
ANNALS OF NEUROLOGY
sì
WOS:000228937300016
2-s2.0-18244406794
Esperti anonimi
Inglese
Internazionale
57
5
738
741
4
15852393
sì
8
info:eu-repo/semantics/article
262
Castelnau, P; Cif, L; Valente, ENZA MARIA; Vayssiere, N; Hemm, S; Gannau, A; Digiorgio, A; Coubes, P.
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1180761
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