OBJECTIVES: Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined. METHODS: A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment. RESULTS: We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1beta and interferon-gamma. CONCLUSIONS: These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.

Antipsychotics' effects on blood levels of cytokines in schizophrenia: A meta-analysis

ROCCHETTI, MATTEO;Fusar Poli, Paolo;
2013

Abstract

OBJECTIVES: Evidence-based medicine suggests that schizophrenia is associated with an inflammatory syndrome, but the extent to which this syndrome is normalized by antipsychotic treatment has yet to be determined. METHODS: A systematic quantitative review of the effects of antipsychotics on peripheral cytokine levels in schizophrenia was performed, using follow-up studies providing in vivo cytokine assessments before and after treatment. RESULTS: We retrieved 23 studies (total of 762 subjects) which showed that antipsychotic treatment significantly increases plasma levels of soluble interleukin-2 receptor and reduces the plasma levels of interleukin-1beta and interferon-gamma. CONCLUSIONS: These results show that antipsychotics produce anti-inflammatory effects in schizophrenia.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11571/1182568
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