Background: The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim: To assess HLA-DRB*1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB*1501 haplotype was determined by genotyping (rs3135388). Results: No significant differences were observed in MRI measures between the HLA-DRB*1501 subgroups. Conclusions: The HLA-DRB*1501 haplotype is not strongly associated with MRI-visible grey matter pathology
HLA-DRB∗1501 associations with magnetic resonance imaging measures of grey matter pathology in multiple sclerosis
GANDINI, CLAUDIA;
2016-01-01
Abstract
Background: The HLA-DRB*1501 haplotype influences the risk of developing multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim: To assess HLA-DRB*1501 effects on magnetic resonance imaging (MRI) cortical grey matter pathology. Methods: Whole and lesional cortical grey matter volumes, lesional and normal-appearing grey matter magnetization transfer ratio were measured in 85 people with MS and 36 healthy control subjects. HLA-DRB*1501 haplotype was determined by genotyping (rs3135388). Results: No significant differences were observed in MRI measures between the HLA-DRB*1501 subgroups. Conclusions: The HLA-DRB*1501 haplotype is not strongly associated with MRI-visible grey matter pathologyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
