Abstract BACKGROUND: There is no universally-accepted classification of spitzoid tumours. This makes difficult to assign a correct diagnosis and select a treatment that minimises the risk of overestimating, or worse, underestimating, the malignant potential of these tumours. To describe the clinical-pathological and epidemiological features of spitzoid tumours, as well as to assess mortality in these patients. METHODS: This retrospective cohort study looked at data on spitzoid tumours excised in 1999-2012 at the Dermatologic Clinic of the Turin University Hospital. Spitzoid melanoma specific survival curves were generated with the Kaplan-Meier method and compared using the log-rank test. RESULTS: in this time period, 1663 lesion were described at the pathologic report as spitzoid. 262 were (15.75%) Spitz naevi, 307 (18.46%) Reed naevi, 827 (49.73%), 810 (48.71%) spitzoid dysplastic naevi, 17(1.02%) atypical spitzoid tumours, and 267 (16.06%) spitzoid melanomas. Median follow up time was 9 years. Out of the entire cohort only 24 patients died from melanoma. All of them received a diagnosis of spitzoid melanoma. None of the patients with a diagnosis of not melanoma spitz tumour died for melanoma during the follow up. CONCLUSION: In the large mayority of the cases, spitz tumour should be considered as benign lesion and excised only if melanoma features are seen. The used clinical pathological classification avoid misdiagnoses, inappropriate treatment and the risk of death for melanoma.
The large spectrum of spitzoid tumours: a retrospective survival study.
TOMASINI, CARLO FRANCESCO;
In corso di stampa
Abstract
Abstract BACKGROUND: There is no universally-accepted classification of spitzoid tumours. This makes difficult to assign a correct diagnosis and select a treatment that minimises the risk of overestimating, or worse, underestimating, the malignant potential of these tumours. To describe the clinical-pathological and epidemiological features of spitzoid tumours, as well as to assess mortality in these patients. METHODS: This retrospective cohort study looked at data on spitzoid tumours excised in 1999-2012 at the Dermatologic Clinic of the Turin University Hospital. Spitzoid melanoma specific survival curves were generated with the Kaplan-Meier method and compared using the log-rank test. RESULTS: in this time period, 1663 lesion were described at the pathologic report as spitzoid. 262 were (15.75%) Spitz naevi, 307 (18.46%) Reed naevi, 827 (49.73%), 810 (48.71%) spitzoid dysplastic naevi, 17(1.02%) atypical spitzoid tumours, and 267 (16.06%) spitzoid melanomas. Median follow up time was 9 years. Out of the entire cohort only 24 patients died from melanoma. All of them received a diagnosis of spitzoid melanoma. None of the patients with a diagnosis of not melanoma spitz tumour died for melanoma during the follow up. CONCLUSION: In the large mayority of the cases, spitz tumour should be considered as benign lesion and excised only if melanoma features are seen. The used clinical pathological classification avoid misdiagnoses, inappropriate treatment and the risk of death for melanoma.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
