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The photochemical metal-free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including heteroand polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide.

A visible light driven, metal-free route to aromatic amides via radical arylation of isonitriles

MALACARNE, MARCO;Protti, Stefano;Fagnoni, M.
2017-01-01

Abstract

The photochemical metal-free carboamidation of aryl radicals has been exploited for the preparation of aromatic amides, including heteroand polyaromatic derivatives, under visible light irradiation of arylazo sulfones in the presence of isocyanides in aqueous acetonitrile. The process was useful for the smooth preparation of the antidepressant moclobemide.
2017
The Organic Chemistry/Polymer Science category includes resources concerned with the related fields of organic chemistry and polymer science. The organic chemistry resources deal with compounds of carbon with the exception of certain simple ones, such as the carbon oxides, carbonates, cyanides and cyanates (see Inorganic & Nuclear Chemistry). This category includes research on synthetic and natural organic compounds that may include other elements, such as hydrogen and oxygen, but also nitrogen, halogens, sulphur and phosphorous. Resources concerned with hydrocarbons, organic compounds containing only the elements carbon and hydrogen, are also included in this category. Examples are the alkanes, alkenes, alkynes and aromatics, such as benzene and naphthalene. Polymer science includes all resources dealing with the study, production and technology of polymers, which are compounds composed of very large molecules made up of repeating molecular units (monomers). Polymers may be natural substances, such as polysaccharides or proteins, or synthetic materials, such as nylon or polyethylene.
ADVANCED SYNTHESIS & CATALYSIS
sì
WOS:000416935100016
2-s2.0-85033448514
Esperti anonimi
Inglese
Internazionale
ELETTRONICO
359
3826
3830
5
Visible light, photochemistry, metal-free synthesis, aromatic amides, aryl radical, isonitriles
https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201700619
no
3
info:eu-repo/semantics/article
262
Malacarne, Marco; Protti, Stefano; Fagnoni, M.
1 Contributo su Rivista::1.1 Articolo in rivista
none
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1204108
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