An infrequent and difficult to treat complication of the neurosurgical removal of a lesion in the frontal or parietal lobes is cortical myoclonus (CM).1,2 Cortical myoclonus has also been linked to focal lesions in the same locations independently from their surgical removal.3,4,5 In the present case and in the majority of the reported cases the paramedian premotor cortex was involved. However, all except one of the lesions that were previously reported, were not adjacent to the primary motor cortex as in our patient (fig. 1a). Treatment of myoclonus can be difficult and polytherapy is often required for an acceptable result6. We present a case of cortical myoclonus that started five days after surgery, was not responsive to benzodiazepine and levetiracetam and resolved only after perampanel administration.
POST-SURGICAL CORTICAL MYOCLONUS RESPONSIVE TO PERAMPANEL
Simonetta BianchiniWriting – Review & Editing
;Andrea AlbergatiWriting – Review & Editing
;Lorenzo Magrassi
Conceptualization
2018-01-01
Abstract
An infrequent and difficult to treat complication of the neurosurgical removal of a lesion in the frontal or parietal lobes is cortical myoclonus (CM).1,2 Cortical myoclonus has also been linked to focal lesions in the same locations independently from their surgical removal.3,4,5 In the present case and in the majority of the reported cases the paramedian premotor cortex was involved. However, all except one of the lesions that were previously reported, were not adjacent to the primary motor cortex as in our patient (fig. 1a). Treatment of myoclonus can be difficult and polytherapy is often required for an acceptable result6. We present a case of cortical myoclonus that started five days after surgery, was not responsive to benzodiazepine and levetiracetam and resolved only after perampanel administration.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
