In recent years, lung cancer has become a serious public health problem, ranking first as leading cause of death among malignant neoplasms. The incidence and mortality of lung cancer have shown an upward trend in many countries2. The main risk factors of lung cancer are smoking, improper diet, alcohol abuse, radiation, air pollution, pulmonary disease, and occupational complications. Although the survival rate is closely related to early diagnosis and resection, the early symptoms of NSCLC are not typical and may even be absent, with little or no discomfort reported3. In addition to first line chemotherapy using docetaxel, pemetrexed and erlotinib to treat patients with advanced NSCLC, several drugs have been approved, but survival rates have not improved in randomized clinical trials4. The efficacy of metronomic chemotherapy in metastatic NSCLC was recently shown to be a possible option5. A new clinical scenario includes lung cancer patients with human immunodeficiency virus (HIV), in which highly active antiretroviral therapy (HAART) has been shown to improve lung cancer prognosis6.
Upregulation of LINC00346 in non-small cell lung cancer cells
Rossi, P.
Membro del Collaboration Group
;Ratto, D.Membro del Collaboration Group
;
2018-01-01
Abstract
In recent years, lung cancer has become a serious public health problem, ranking first as leading cause of death among malignant neoplasms. The incidence and mortality of lung cancer have shown an upward trend in many countries2. The main risk factors of lung cancer are smoking, improper diet, alcohol abuse, radiation, air pollution, pulmonary disease, and occupational complications. Although the survival rate is closely related to early diagnosis and resection, the early symptoms of NSCLC are not typical and may even be absent, with little or no discomfort reported3. In addition to first line chemotherapy using docetaxel, pemetrexed and erlotinib to treat patients with advanced NSCLC, several drugs have been approved, but survival rates have not improved in randomized clinical trials4. The efficacy of metronomic chemotherapy in metastatic NSCLC was recently shown to be a possible option5. A new clinical scenario includes lung cancer patients with human immunodeficiency virus (HIV), in which highly active antiretroviral therapy (HAART) has been shown to improve lung cancer prognosis6.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
