C–H arylations of oxazolines were accom- plished with a well-defined palladium catalyst de- rived from a secondary bisdiamantyl phosphine oxide. The single-component secondary phosphine oxide (SPO)-palladium complex enabled C–H activa- tions with aryl bromides and challenging aryl chlor- ides in the absence of directing groups, setting the stage for the step-economical synthesis of pybox li- gands under racemization-free reaction conditions.
Secondary Phosphine Oxide Preligands for Palladium-Catalyzed CâH (Hetero)Arylations: Efficient Access to Pybox Ligands
GHORAI, DEBASISH;Zanoni, Giuseppe;ACKERMANN, LUTZ
2017-01-01
Abstract
C–H arylations of oxazolines were accom- plished with a well-defined palladium catalyst de- rived from a secondary bisdiamantyl phosphine oxide. The single-component secondary phosphine oxide (SPO)-palladium complex enabled C–H activa- tions with aryl bromides and challenging aryl chlor- ides in the absence of directing groups, setting the stage for the step-economical synthesis of pybox li- gands under racemization-free reaction conditions.File in questo prodotto:
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