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Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. This combination was evaluated in Ewing sarcoma patient who was progressing with standard therapies.

Targeting the EWS-FLI1 transcription factor in Ewing sarcoma

Tancredi, R;Riccardi, A;
2015-01-01

Abstract

Preclinical data indicate there is strong synergism of action against Ewing sarcoma in sequential treatment with trabectedin followed by irinotecan and it appears to be related to a selective blockade of the transcription factor EWS-FLI1. This combination was evaluated in Ewing sarcoma patient who was progressing with standard therapies.
2015
Oncogenesis & Cancer Research covers research into all aspects of tumorigenesis in vitro as well as the occurrence and pathogenesis of cancer. Emphasis is placed on molecular regulation of cell growth, oncogene expression/function in normal and transformed cells, mechanisms of anti-cancer drug action, and experimental therapeutics. Excluded from this category are resources dealing with the treatment of cancer in humans. Resources concerned with cell growth and differentiation without specific application to mechanisms of oncogenesis are excluded; this material is covered in the Cell & Developmental Biology category.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
sì
WOS:000354949000024
2-s2.0-84929711731&
Esperti anonimi
Inglese
Internazionale
STAMPA
75
6
1317-20
25809543
Adult; Camptothecin; Dioxoles; Humans; Male; Oncogene Proteins, Fusion; Proto-Oncogene Protein c-fli-1; RNA-Binding Protein EWS; Sarcoma, Ewing; Tetrahydroisoquinolines
sì
9
info:eu-repo/semantics/article
262
Tancredi, R; Zambelli, A; Daprada, G A; Fregoni, V; Pavesi, L; Riccardi, A; Burdach, S; Grohar, P J; D'Incalci, M
1 Contributo su Rivista::1.1 Articolo in rivista
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1.1 Articolo in rivista
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1211201
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