Cytokines are immunomodulatory and inflammatory compounds produced by many different Cell types The IL-1 family consists of at least eleven cytokines. including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate inflammation IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and inflammation Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4 Here we review the interrelationship between PGD2, IL-1 family members and mast cells

PGD2, IL-1-family members and mast cells

GALZIO R;
2010-01-01

Abstract

Cytokines are immunomodulatory and inflammatory compounds produced by many different Cell types The IL-1 family consists of at least eleven cytokines. including IL-18 and IL-13 and are essential to the host defence against severe infections and mediate inflammation IL-18 also enhances tumour rejection and has high capacity to augment the cytotoxicity of NK cells and T cells IL-33 stimulates basophils and mast cells to produce cytokines and histamine independently of IgE Mast cells play a crucial role in the development of allergy through the cross-linking of their surface receptors for IgE leading to degranulation and inflammation Activated mast cells induce the generation of PGD2, detectable in 2-15 minutes after challenge, and LTC4 Here we review the interrelationship between PGD2, IL-1 family members and mast cells
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11571/1220992
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 15
social impact